Research progress of exosomes in noninfectious uveitis

Authors: Liu Zijia,  Gong Yuanyuan
DOI: 10.3760/cma.j.cn115989-20211022-00574
 

Citation

Liu Zijia,  Gong Yuanyuan. Research progress of exosomes in noninfectious uveitis[J]. Chin J Exp Ophthalmol, 2024, 42(11):1043-1047. DOI: 10.3760/cma.j.cn115989-20211022-00574.

ABSTRACT                   [Download PDF] [Read Full Text]

Noninfectious uveitis (NIU) is a refractory disease that could lead to blindness.Lack of specific NIU indicators sometimes causes a delay in diagnosis and treatment, due to its diverse etiology, complex mechanism, and the long course of disease.Empirically, the clinical emphasis is to optimize diagnosis and treatment methods and reduce complications.Recent studies on exosomes have shown their regulatory effect on inflammation, suggesting that they have application potential in the diagnosis and treatment of uveitis.Exosomes are cell-derived cystic vesicles, containing a variety of effector biomolecules and biomarkers.They can penetrate biological barriers, mediate intercellular communication, and be used as drug carriers in clinical treatment.However, research on exosomes in fundus diseases, especially in uveitis, is still in its infancy.This article reviews advanced research, hypothesis, and possible translational applications of exosomes in NIU to provide new ideas for the diagnosis and treatment of the disease.

Noninfectious uveitis;Exosome;Immunity;Inflammation

Authors Info & Affiliations 

Liu Zijia
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200080, China
Gong Yuanyuan
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200080, China
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