Manganese-enhanced MRI (MEMRI) optic nerve tracing in vivo is a technology which can reflect the axonal transport status and visual pathway connection by utilizing divalent manganese ion’s transportability in axons and its characteristics of paramagnetism, and such potential optic nerve tract-tracing technique has been widely used in ophthalmologic research.Mn2+ enters the neurons through the voltage-gating Ca2+ channel and is transported by microtubule system which is not depended on cellular electric activity.However, the trans-synaptic transport of Mn2+relies on membrane potential.Taking advantages of MEMRI, optic nerve injury-related research could be implemented.Mn2+ is an intracellular contrast agent with metal toxicity, so low dose, fractionated, targeted delivery of Mn2+ is recommended to alleviate the adverse effects of Mn2+ .Herein, the mechanism of divalent manganese ion optic nerve tracing, application of MEMRI in ophthalmologic research field, drug delivery approach of divalent Mn2+and its toxicity were summarized.
Authors：Chen Yao, Hu Yuntao, Ma Zhizhong
Cite as Chin J Exp Ophthalmol, 2016,34(6): 562-565.
Manganese; MRI; Optic nerve
Department of Ophthalmology, Beijing Tsinghua Changgung Hospital, Beijing 102218, China
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