Research progress of nucleotide-binding oligomerzation domain like receptors 3 inflammasome in age-related macular degeneration

Authors: Sun Mengsha,  Yan Quan,  Sun Xiaodong
DOI: 10.3760/cma.j.issn.2095-0160.2019.01.017
Published 2019-04-10
Cite as Chin J Exp Ophthalmol, 2019,37(4): 316-320.

Abstract

Age-related macular degeneration (AMD) is a multifactorial neurodegenerative disease characterized by the deterioration of the macula resulting in impaired visual acuity, which could probably cause irreversible vision loss.The pathogenesis of AMD is not clear yet though it has been found related to inflammation.As an important component of innate immunity, nucleotide-binding oligomerzation domain like receptors 3 (NLRP3) inflammasome may play a role in AMD.This article reviewed the progress in the studies of the role of NLRP3 inflammasome in AMD via discussing the activation mechanism of it, which may provide a novel treatment strategy of AMD by targeting NLRP3 inflammasome.

Key words:

Age-related macular degeneration; Inflammation; Nucleotide-binding oligomerzation domain like receptors 3; Inflammasome

Contributor Information

Sun Mengsha
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Fundus Disease, Shanghai 200080, China
Yan Quan
Sun Xiaodong
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Updated: September 3, 2019 — 1:30 pm