Research progress of programmed cell death 1 and its receptor programmed cell death 1 ligand 1 in the pathogenesis of eye diseases

Authors: Tian Xuelian,  Tang Li
DOI: 10.3760/cma.j.cn115989-20190912-00393
Published 2021-05-10
Cite asChin J Exp Ophthalmol, 2021, 39(5): 464-468.

Abstract

Programmed cell death 1 (PD-1) is an important negative costimulatory molecule discovered in recent years, which is expressed on the surface of T and B cells and plays an important role in the regulation of cellular immune response and immune tolerance.After the combination of PD-1 and its receptor programmed cell death 1 ligand 1 (PD-L1), negative regulatory signals are transmitted to suppress the immune response.Under the activation of stimulating factors, PD-1 and PD-L1 are combined to weaken the conduction of downstream signaling pathways such as PI3K/Akt and ERK through recruitment of phosphorylated SHP2, thereby inhibiting the proliferation of T cells and the production of cytokines, inhibiting the immune response and participating in the occurrence and development of a large number of inflammatory diseases.PD-1 in the field of ophthalmology research is still in its infancy.As far as we know, PD-1 participates in ocular inflammatory diseases such as uveitis, sympathetic ophthalmia, allergic conjunctivitis, also is involved in corneal transplant rejection, optic nerve crush injury and optic myelitis, diabetic retinopathy, thyroid related ophthalmopathy, melanoma and other diseases, thus preventing the interactions between PD-1 and its receptor PD-L1 may become a new potential target for the treatment of ocular tumor, inflammation, autoimmune and neurodegeneration disease.In this article, the latest research progress of PD-1 and its receptor PD-L1 in the pathogenesis of ocular diseases were reviewed.

Key words:

Programmed cell death 1; Eye disease; Autoimmune disease

Contributor Information

Tian Xuelian

Department of Ophthalmology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China

Tang Li

Department of Ophthalmology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China

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Updated: May 27, 2021 — 2:55 am