Citation
ABSTRACT [Download PDF] [View Full Text]
Oxidative stress and its closely related pathophysiological processes of vascular damage and inflammation have been recognized as important pathogenic mechanisms in many ocular diseases.Kaempferol, a natural flavonoid compound, exhibits great promise in preventing and treating various eye disorders due to its potent antioxidant, anti-inflammatory, and anti-angiogenic activities.In dry eye models, kaempferol effectively suppresses ocular surface inflammation, promotes corneal repair, and increases tear secretion.In glaucoma treatment, kaempferol protects retinal ganglion cells and alleviates optic nerve damage.For retinal degenerative diseases, such as age-related macular degeneration, kaempferol protects retinal pigment epithelial cells from oxidative stress-induced damage and apoptosis.In ocular neovascular diseases, which encompass corneal, retinal, and choroidal neovascularization, kaempferol effectively blocks pathological neovascularization formation by inhibiting the expression and signaling of key proangiogenic factors, such as vascular endothelial growth factor.Kaempferol has significant therapeutic potential for multiple eye diseases through multi-target mechanisms, and its further research will provide a scientific basis for its clinical application and development of innovative therapeutics.This review summarizes recent advances in kaempferol research in ophthalmology.