Research progress on the protection of ischemic conditioning against retinal ischemic diseases

Authors:  Gao Yuan,  Ren Changhong,  Zhang Xuxiang

DOI: 10.3760/cma.j.issn.2095-0160.2018.06.014
Published 2018-06-10
Cite as Chin J Exp Ophthalmol, 2018,36(6): 468-471.

Abstract

Retinal ischemic diseases, such as retinal vascular obstruction, diabetic retinopathy, glaucoma, and retinopathy of prematurity, are one of the common causes of visual loss.However, there are no safe and effective treatments at present.Ischemic conditioning is an endogenous protective measure, of which protection in the prevention of cardiovascular and cerebrovascular diseases has been confirmed.Ischemic conditioning can initiate endogenous neuroprotective mechanisms to reduce retinal ischemia-reperfusion injury, improve retinal tolerance to ischemia, protect retinal ganglion cells, optic disc structure and function from glaucoma, and prevent the progress of diabetic retinopathy in a variety of ways.This article summarized the research from the aspects of the conception, the protective effect on retinal and related mechanism of ischemic conditioning, which provide basic research transferring to clinical research of ischemic conditioning on retinal ischemic diseases in future for the theoretical and experimental proofs.

Key words:

Ischemic conditioning; Retinal; Protection

Contributor Information

Gao Yuan
Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Ren Changhong
Laboratory of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Zhang Xuxiang
Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
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