Role of micro RNA in glaucoma

Authors: Li Ning,  Duan Xuanchu
DOI: 10.3760/cma.j.issn.2095-0160.2019.04.015
Published 2019-04-10
Cite as Chin J Exp Ophthalmol, 2019,37(4): 308-311.

Abstract

Nowadays, the pathogenesis of primary glaucoma is unclear yet, and the treatment is tricky.MicroRNA (miRNA) is a small molecule non-coding RNA, which could inhibit the target mRNA, specifically.miRNA can regulate post-transcriptional expression, and it plays an important role in the process of cell proliferation, apoptosis, differentiation, orgnic development and metabolism.Researches in recent years found that miRNA plays an important regulatory role in the process of glaucoma, such as aqueous secretion, intraocular pressure fluctuation, trabecular meshwork remodeling, anti-glaucoma surgery filtration scarring and nerve regeneration.In this review, we summarized the mechanism of miRNA in glaucomatous lesions, and looked ahead to the future of drug targeting research in glaucoma.

Key words:

Glaucoma; microRNA; Gene expression; Diagnosis and therapeutic approach

Contributor Information

Li Ning
Department of Ophthalmology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Duan Xuanchu
Department of Ophthalmology, the Second Xiangya Hospital of Central South University, Changsha 410011, China
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Updated: September 3, 2019 — 1:30 pm