Studies on pathogenesis and gene therapy of red-green color blindness

Authors:  Xu Fan,  Pang Jijing

DOI: 10.3760/cma.j.issn.2095-0160.2018.07.014
Published 2018-07-10
Cite as Chin J Exp Ophthalmol, 2018,36(7): 549-552.

Abstract

Red-green color blindness is the most common form of colour blindness.Traditional treatment options such as tinted lenses do not cure color blindness completely.With the rapid development of gene diagnostic and managing technology, gene therapy has been applied to inherited retinal diseases widely.The genetic treatment of Leber congenital amaurosis has entered clinical trail and shown the remarkable success in safety and efficacy.In recent years, gene therapy has finally reached a milestone to convert adult male squirrel monkeys with red-green color blindness to trichromats.It heralds the bright prospects of gene therapy applied in human red green color blindness.This article briefly reviewed the recent preclinical research achievements of pathogenesis and gene therapy for red-green color blindnes.

Key words:

Red-green color blindness; Pathogenesis; Gene therapy

Contributor Information

Xu Fan
Department of Ophthalmology, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
Pang Jijing
Xiamen Eye Centre of Xiamen University, Hua Xia Eye Hospital Group, Xiamen 361000, China
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