The role of autophagy and potential therapeutic effect of autophagy regulation in cornea diseases

Authors: Zou Xuexiang,  Li Juan

DOI: 10.3760/cma.j.issn.2095-0160.2019.02.011
Published 2019-02-10
Cite as Chin J Exp Ophthalmol, 2019,37(2): 129-133.

Abstract

Autophagy is a metabolic process of lysosomal-mediated degradation of damaged proteins or aging organelles, which plays an important role in maintaining the stability of intracellular environment and achieving cell metabolism and circulation.Recent studies have shown that autophagy is closely related to the development of many ocular diseases, including cataract, glaucoma, retinal detachment, diabetic retinopathy and age-related macular degeneration.In keratopathy, including granular corneal dystrophy type 2 (GCD2), Fuchs corneal endothelium dystrophy (FECD), keratitis, keratoconus (KC), corneal injury and repair, dry eye and so on, autophagic disorder can affect corneal transparency, and even lead to blindness.Regulating autophagic activity may be one of the hotspots in the study of corneal disease.This article reviews the role of autophagy and the potential therapeutic effect of autophagy regulation in cornea diseases.

Key words:

Autophagy; Cornea diseases; Therapy

Contributor Information

Zou Xuexiang
Shaanxi Ophthalmic Medical Center, Department of Ophthalmology, Xi’an No.4 Hospital, Affiliated Guangren Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710004, China (is working at the Sixth Affiliated Hospital of Guangzhou Medical University, Department of Ophthalmology, Qingyuan People’s Hospital, Qingyuan 511518, China)
Li Juan
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Updated: September 4, 2019 — 6:01 am