The role of gut microbiota in eye diseases

Authors: Geng Chao,  Li Yahong,  Zhang Yan
DOI: 10.3760/cma.j.cn115989-20190701-00281
Published 2022-08-10
Cite asChin J Exp Ophthalmol, 2022, 40(8): 785-790.

Abstract                               [View PDF] [Read Full Text]

In recent years, the study of symbiotic microbial community on human health and disease has gradually become a hot spot.In particular, the Human Microbiome Project and the emergence of 16S rRNA gene sequencing technology have further promoted the study of human-related microbiota.The gut microbiota is the largest microecosystem of the human body.Normal gut microbiota plays an important role in maintaining host immune balance, promoting nutrient metabolism and sustaining intestinal homeostasis.At present, there is increasing evidence that gut microbiota disorders are associated with a variety of diseases, not only having an impact on the intestinal tract but also affecting many extraintestinal tissues and organs.With the emergence of the concept of gut-brain axis, which interacts between gut microbiota and brain, some researchers suggest that there may also be gut-eye axis between gut microbiota and eye.This review summarized the recent research advances on the role of gut microbiota in ophthalmic diseases, including corneal diseases, uveitis, retinopathies, and the ophthalmic diseases associated with systemic diseases, in the hope that it could provide evidence for the existence of gut-eye axis and new idea for the treatment of ophthalmic diseases in the future.

Key words:

Gastrointestinal microbiome/physiology; Ophthalmic disease; Immunity, innate; Gut-eye axis

Contributor Information

Geng Chao

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China

Li Yahong

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China

Zhang Yan

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China

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