Advance in the risk factors and pathogenesis of Demodex blepharitis

Demodex is a common small parasite in the human body, with a body length of about 150-350 μm and mainly found in human sebaceous glands and skin hair follicles.In recent years, numerous studies in dermatology and ophthalmology have shown that Demodex is related to the occurrence and development of rosacea, blepharitis and other diseases.Demodex blepharitis has become one of the clinical concerns.Demodex blepharitis is an inflammation in the skin of the eyelid margin caused by Demodex infection.In severe cases, cornea and conjunctiva can be involved, and vision can be affected.Demodex blepharitis is a widespread and easily overlooked disease.Up to 90% of patients with blepharitis are infected with Demodex, and the main pathogenic diagnostic methods are light microscopy and in vivo confocal microscopy.At present, the treatment of Demodex blepharitis is mainly to remove mites by metronidazole and tea tree oil etc.Its risk factors and pathogenesis are not fully understood yet.This article mainly summarized and analyzed the research progress on the risk factors for Demodex blepharitis and its possible pathogenesis at home and abroad in order to provide references for further research and clinical treatment.