Application of local injection of botulinum toxin A in the treatment of strabismus

Botulinum toxin A (BTA), a kind of botulinum exotoxin, which may cause muscular paralysis by the impact of chemical denervation, is commonly utilized in ophthalmology, dermatology, and medical plastic surgery.In the field of ophthalmology, it was first employed to address infantile esotropia, acute concomitant esotropia, nerve paralytic strabismus, and other kinds of strabismus.In recent years, some ophthalmologists have attempted to use BTA to correct partial accommodative esotropia, restrictive strabismus and exotropia, and found that BTA may be used as an alternate approach for extraocular muscles surgery in specific forms of strabismus, such as acute concomitant esotropia, partial accommodative esotropia and infantile esotropia (≤30 prism diopter), and can enhance the effect of surgical correction in the correction of large-angle infantile esotropia and sensory exotropia.This provides a new notion for the treatment of different types of strabismus.At the same time, by improving the injection technique and using the dose increment to control the drug dosage, the local drug utilization rate has been increased, and the complications has been reduced.The mechanism, efficacy, safety, and dosage of BTA in the correction of strabismus are discussed in this article, and the efficacy of BTA in correction of various types of strabismus is analyzed and compared to provide references for the use of BTA in strabismus.

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