Authors: Li Shaoheng, Wang Yusheng, Su Yuting
DOI: 10.3760/cma.j.cn115989-20241014-00288
Published: 2026 -01 -10
Citation
Li Shaoheng, Wang Yusheng, Su Yuting. Research progress on the pathogenesis and animal models of pachychoroid spectrum disorders[J]. Chin J Exp Opthalmol, 2026, 44(1):61-66. DOI: 10.3760/cma.j.cn115989-20241014-00288.
ABSTRACT [Download PDF] [Read Full Text]
Pachychoroid spectrum disorders (PDS) represent a group of diseases characterized by choroidal thickening and retinal pigment epithelial abnormalities, encompassing subtypes such as central serous chorioretinopathy, polypoidal choroidal vasculopathy, pachychoroid neovasculopathy, and pachychoroid pigment epitheliopathy. The pathogenesis of these disorders is complex, involving pathological processes such as vortex vein abnormalities, venous overload, and retinal pigment epithelium dysfunction, and is influenced by both genetic and environmental factors. In recent years, the application of imaging technologies such as optical coherence tomography and optical coherence tomography angiography has significantly enhanced the diagnostic accuracy and research depth of these diseases. However, challenges persist in precise subtype prediction and targeted therapies. This article systematically reviews the classification, epidemiological features, and pathogenesis of PDS, explores its pathological basis in combination with animal models, and provides an outlook on future research directions in diagnostic optimization, therapeutic innovation, and personalized management of PDS, with the aim of offering a theoretical foundation for a comprehensive understanding and scientific management of PDS.
KEYWORDS：
Pachychoroid spectrum disease; Choroid; Pathogenesis; Animal models
Authors Info & Affiliations
Li Shaoheng
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Wang Yusheng
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Su Yuting
Aerospace Clinical Medical Center, School of Aerospace Medicine, Air Force Military Medical University, Xi’an 710032, China