The relationship between primary open angle glaucoma and blood flow abnormalities

As one of the common types of glaucoma, primary open angle glaucoma (POAG) occurs insidiously with conditions, such as patients have normal intraocular pressure while accompanying with glaucomatous optic nerve damage, or the intraocular pressure is reduced to normal range, while the disease is still progressing.Additionally, the control and prevention of corresponding disease remain difficult.This paper summarized the ocular and systemic blood flow abnormalities in POAG, including high resistance and low flow rate of the ocular blood, reduction of vascular density in the eye, systemic vascular dysregulation, hemorheology change, as well as abnormalities in blood pressure and nailfold microcirculation.Keeping in mind the impact of these abnormalities on the occurrence and development of POAG, this paper analyzed the mechanism of glaucomatous optic nerve damage caused by abnormal blood flow and strengthened the understanding of blood flow theory in the pathogenesis of POAG.The ultimate goal is providing a novel thought for future research in POAG.