A review of the association between nuclear receptors and ocular diseases

Nuclear receptor is one of abundant transcription factors in human body.Interacted with corresponding ligands, coactivators and corepressors, nuclear receptor can regulate the expression of genes and plays important roles in the development, cell differentiation, physiological and metabolic processes.Many diseases are directly or indirectly linked to nuclear receptor, which is the reason why nuclear receptor has recently attracted widespread attention.In recent years, a large number of studies have found that the abnormal expression of nuclear receptor is associated with a variety of ocular diseases.It is worth noting that nuclear receptor related target drugs in some refractory diseases, especially diabetes and some cancers such as prostate cancer and breast cancer have be used in clinic.It is not difficult to see the prospect of nuclear receptors.Continual exploration of the relationship between nuclear receptors and ocular diseases not only has an important significance in the study of the occurrence and development of diseases, but also brings new inspiration in the treatment.These studies make target therapy become a reality, and even make individualized medication possible.This article mainly reviewed the basic background knowledge of nuclear receptor and the relationship between nuclear receptor and ocular diseases.