A review of the association between nuclear receptors and ocular diseases

Authors:Liu Ke,  Qin Bo,  Zou Chang
DOI: 10.3760/cma.j.issn.2095-0160.2016.11.017
Published 2016-11-10
Cite as Chin J Exp Ophthalmol, 2016,34(11): 1042-1046.

Abstract

Nuclear receptor is one of abundant transcription factors in human body.Interacted with corresponding ligands, coactivators and corepressors, nuclear receptor can regulate the expression of genes and plays important roles in the development, cell differentiation, physiological and metabolic processes.Many diseases are directly or indirectly linked to nuclear receptor, which is the reason why nuclear receptor has recently attracted widespread attention.In recent years, a large number of studies have found that the abnormal expression of nuclear receptor is associated with a variety of ocular diseases.It is worth noting that nuclear receptor related target drugs in some refractory diseases, especially diabetes and some cancers such as prostate cancer and breast cancer have be used in clinic.It is not difficult to see the prospect of nuclear receptors.Continual exploration of the relationship between nuclear receptors and ocular diseases not only has an important significance in the study of the occurrence and development of diseases, but also brings new inspiration in the treatment.These studies make target therapy become a reality, and even make individualized medication possible.This article mainly reviewed the basic background knowledge of nuclear receptor and the relationship between nuclear receptor and ocular diseases.

Key words:

Nuclear receptors; Ocular diseases; Targeted therapy

Contributor Information

Liu Ke
Department of Ophthalmology, The Second Clinical College of Jinan University, Guangzhou 510632, China (now Shenzhen Eye Hospital, Affiliated Shenzhen Eye Hospital of Jinan University)
Qin Bo
Shenzhen Eye Hospital, Affiliated Shenzhen Eye Hospital of Jinan University, Joint College of Optometry of Shenzhen University, Shenzhen Key Laboratory of Ophthalmology, Ocular Trauma Treatment and Stem Cell Differentiation Public Service Platform of Shenzhen, Shenzhen 518040, China
Zou Chang
The Second Clinical Collage of Jinan University, The People’s Hospital of Shenzhen, Clinical Research Centre, Shenzhen 518000, China
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