A systematic review of metabolomic studies on the mechanism of myopia

Authors: Liu Shang,  Xiong Shuyu,  He Xiangui
DOI: 10.3760/cma.j.cn115989-20200613-00429
Published 2023-04-10
Cite as Chin J Exp Ophthalmol, 2023, 41(4): 392-397.

Abstract                              [Download PDF] [Read Full Text]

Myopia has become a global public health concern with its increasing prevalence.It is the interaction result of genetic and environmental factors.Exploration of the changes of metabolites in myopia is helpful to know new clues about its pathogenic mechanism.Metabolomics focuses on the integral analysis of all small molecular metabolites (relative molecular mass <1 000) which form a biological system and it is used as an effective tool to discover potential biomarkers.Metabolomic analysis of the myopic population could discover the metabolic changes related to myopia and screen the markers with potential biological significance, which can be used in the early diagnosis and treatment of myopia.It has been found that metabolites related to oxidative stress and inflammation play an important role in the development of myopia.Abnormal energy metabolism and amino acid metabolism are associated with myopic fundus changes.In addition, classical myopia-associated metabolites such as retinoic acid, dopamine and vitamin D, other metabolites such as melatonin, cyclic adenosine monophosphate and 5-hydroxy indole acetic acid, as well as multiple metabolic pathways such as fatty acid metabolism and mitochondrial metabolism are all closely related to myopia.This article systematically reviewed metabolomics researches on myopia, providing clues for better prevention and control of myopia in the future.

Key words:

Myopia; Metabolomics; Metabolites; Metabolic pathways

Contributor Information

Liu Shang

Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai 200040, China

Xiong Shuyu

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School, National Eye Disease Clinical Medicine Research Center, Shanghai Children and Adolescent Myopia Prevention and Treatment Technology Center, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai 200080, China

He Xiangui

Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai 200040, China

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School, National Eye Disease Clinical Medicine Research Center, Shanghai Children and Adolescent Myopia Prevention and Treatment Technology Center, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai 200080, China

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