Actively carry out the molecular genetic study of glaucoma in children

Authors: Chen Xueli,  Chen Yuhong,  Chen Junyi,  Sun Xinghuai
DOI: 10.3760/cma.j.cn115989-20200420-00274
Published 2020-05-10
Cite as Chin J Exp Ophthalmol, 2020,38(05): 377-380.

Abstract

The pathogenesis and clinical manifestations of glaucoma in children are quite complex and diverse.Because the visual function of childhood is in a developing stage, even the intraocular pressure is controlled well, the visual function of childhood glaucoma patients is often poor from ametropia and amblyopia.So the prognosis is unsatisfying.New diagnostic classification of childhood glaucoma of the World Glaucoma Association showed that, except for glaucoma associated with acquired conditions and secondary glaucoma following cataract surgery, ocular anterior segment dysplasia in tissue structure and genetic factors are involved in the pathogenesis to different degrees in other classifications of childhood glaucoma.Therefore, it is very important for researchers to actively carry out genetic evaluation for childhood glaucoma.Current research status of molecular genetics in childhood glaucoma is briefly described here to emphasize that the researchers should make full use of available disease resources in China to carry out the study of molecular genetics in the diagnosis and classification of childhood glaucoma, which can provide more evidences for the prevention and treatment of blindness in children and healthy birth policy.

Key words:

Glaucoma/genetic; Childhood; Molecular genetics; Anterior segment dysgenesis

Contributor Information

Chen Xueli
Department of Ophthalmology and Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, NHC Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China
Chen Yuhong
Department of Ophthalmology and Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, NHC Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China
Chen Junyi
Department of Ophthalmology and Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, NHC Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China
Sun Xinghuai
Department of Ophthalmology and Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, NHC Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China
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Updated: June 24, 2020 — 11:11 am