Advance in biomarkers of neuromyelitis optica

Authors: Chen Jun,  He Jianfeng,  Zhan Jialin

 DOI: 10.3760/cma.j.issn.2095-0160.2018.12.016
Published 2018-12-10
Cite as Chin J Exp Ophthalmol, 2018,36(12): 973-976.

Abstract

Neuromyelitis optica (NMO) is an autoimmune, demyelinating disease of the central nervous system manifesting with optic neuritis and longitudinally extensive transverse myelitis.Aquaporin-4 (AQP4)-IgG is currently regarded as a specific biomarker of NMO.Nevertheless, AQP4-IgG seronegativity in 10%-25% of NMO patients suggests that there are several other factors involved in NMO immunopathogenesis.In this article, we reviewed current knowledge about biomarkers of NMO from AQP4, myelin-oligodendrocyte glycoprotein, AQP1 and glial fibrillary acidic protein, providing a new insight in the diagnosis of NMO.

Key words:

Neuromyelitis optica; Aquaporin-4; Myelin-oligodendrocyte glycoprotein; Aquaporin-1; Glial fibrillary acidic protein

Contributor Information

Chen Jun
Department of Ophthalmology, Affiliated First Hospital of Guangxi Medical University, Nanning 530027, China
He Jianfeng
Zhan Jialin
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Updated: November 14, 2019 — 12:17 pm