Authors: Pei Chao, Feng Jun
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Retinal vein occlusion (RVO) is a common retinal vascular disease that causes vision loss.The etiology of RVO is complex and its pathogenesis has not yet been fully elucidated.With the development of modern medical technology, there are more and more methods to induce animal models of RVO.Laser photocoagulation and photodynamic therapy (PDT) are the main induction methods for animal models of RVO.Up to now, animal models of RVO have been successfully induced by laser photocoagulation or PDT in many animal species (e.g., mouse, rabbit, pig and monkey). The fundus of different animals can exhibit clinical characterization and histopathological features that approximate those typical of human RVO.In addition, animal model of RVO induced by laser photocoagulation or PDT still lacks standard experimental parameters and has its own advantages and limitations.Therefore, methods of establishing an ideal animal model of RVO on the basis of previous experience, importance for the study of the etiology, pathology and drug intervention of human RVO are reviewed in this article.