Predictive value of OCT parameters to prognosis of anti-VEGF therapy for macular edema secondary to retinal vein occlusion

Authors: Tang Fusheng,  Lu Jianmin,  Ma Xiang

DOI: 10.3760/cma.j.cn115989-20200519-00358
Published 2020-07-10
Cite as Chin J Exp Ophthalmol, 2020,38(07): 625-628.

Abstract

Macular edema secondary to retinal vein occlusion (RVO) is the leading cause of visual impairment in patients with RVO.Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is the first-line treatment for RVO and most of patients can obtain improvements of macular morphology and visual function.Optical coherence tomography (OCT) can clearly characterize the macular microstructure.Qualitative or quantitative analysis of histological retinal layers of the macula, before and after anti-VEGF treatment, can guide the clinical treatment and predict visual outcome of patients with RVO.OCT predictors of visual prognosis in patients with RVO following anti-VEGF treatment, including central retinal thickness, disruption of external limiting membrane and ellipsoid zone, hyperreflective foci, disorganization of the retinal inner layers, serous retinal detachment or intraretinal cystoid spaces, subretinal hemorrhage, vitreomacular adhesion and retinal pigment epithelium (RPE) integrity are focused on in this review, aiming to enhance patient counseling and improve risk assessment and advance clinical management.

Key words:

Tomography, optical coherence; Retinal vein occlusion; Anti-vascular endothelial growth factor; Predictive factors

Contributor Information

Tang Fusheng
Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
Lu Jianmin
Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
Ma Xiang
Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
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Updated: July 27, 2020 — 1:22 am