Advances in animal models of retinal vein occlusion induced by laser photocoagulation and photodynamic therapy

Authors: Pei Chao,  Feng Jun

DOI: 10.3760/cma.j.cn115985-2019-0409-00174
Published 2020-07-10
Cite as Chin J Exp Ophthalmol, 2020,38(07): 621-624.

Abstract

Retinal vein occlusion (RVO) is a common retinal vascular disease that causes vision loss.The etiology of RVO is complex and its pathogenesis has not yet been fully elucidated.With the development of modern medical technology, there are more and more methods to induce animal models of RVO.Laser photocoagulation and photodynamic therapy (PDT) are the main induction methods for animal models of RVO.Up to now, animal models of RVO have been successfully induced by laser photocoagulation or PDT in many animal species (e.g., mouse, rabbit, pig and monkey). The fundus of different animals can exhibit clinical characterization and histopathological features that approximate those typical of human RVO.In addition, animal model of RVO induced by laser photocoagulation or PDT still lacks standard experimental parameters and has its own advantages and limitations.Therefore, methods of establishing an ideal animal model of RVO on the basis of previous experience, importance for the study of the etiology, pathology and drug intervention of human RVO are reviewed in this article.

Key words:

Retinal vein occlusion; Animal model; Laser photocoagulation; Photodynamic therapy

Contributor Information

Pei Chao
Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China
Feng Jun
Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China
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Updated: July 27, 2020 — 1:24 am