Advances in molecular genetics of exfoliation syndrome

Authors: Yin Yan,  Fan Ning,  Liu Xuyang
DOI: 10.3760/cma.j.issn.2095-0160.2015.08.019
Published 2015-08-10
Cite as Chin J Exp Ophthalmol, 2015,33(8): 760-763.

Abstract                            [Download PDF] [Read Full Text]

Exfoliation syndrome (XFS), one of the most common causes of glaucoma, represents an age related, complex, multifactorial and late-onset disease worldwide. The etiopathogenesis involves both genetic and environmental factor. However, the exact etiopathogenesis of XFS is still unclear. The purpose of this review was to discuss the recent research progress of the molecular genetics of XFS. Some candidate genes linked to XFS include lysyl oxidase-like 1 (LOXL1) gene, clusterin (CLU)gene, contactin associated protein-like 2 (CNTNAP2) gene, apolipoprotein E (ApoE) gene, matrix metallo proteinases (MMPs) gene, glutathione S-transferase (GST) gene, transforming growth factor-β1(TGFβ1) gene, tumor necrosis factor-α (TNF-α)gene and so on. These genes may be modifying genes for the development of XFS.

Key words:

Exfoliation syndrome; Molecular genetics; Gene

Contributor Information

Yin Yan
The Centrol Laboratory, The Third People’s Hospital of Yunnan Province, Kunming 650011, China
Fan Ning
Liu Xuyang
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