Abstract [Download PDF] [Read Full Text]
Background
Diabetic retinopathy (DR) has become the main cause of blindness in the world, But the etiology of DR is still not clear, and the results of the studies on the risk factors of DR are not completely consistent.Fully understanding the risk factors of DR has an important clinical value for the prevention and treatment of DR.
Objective
This study was to analyze the prevalence rate and risk factors of DR inpatients with type 2 diabetes and provide a basis for the establishment of ophthalmic intervention programs and measures for diabetic inpatients.
Methods
Cross sectional study was performed.Four hundred and seventy three patients with type 2 diabetes in the department of endocrinology, Dongguan People’s Hospital from July 2011 to July 2012 were included.The patients were divided into DR group and non diabetic retinopathy (NDR) group.The DR group was subdivided into mild, moderate and severe non-proliferative DR (NPDR) group and proliferative DR (PDR) group.The sex and age of patients, course of diabetes, body mass index (BMI), systolic blood pressure, diastolic blood pressure, fasting blood glucose (FBG), 2 hours postprandial blood glucose (2 h PBG), glycosylated hemoglobin (HbA1c), fasting insulin, 2 hours postprandial insulin, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A1 (APOA1), APOB, alpha lipoprotein, total cholesterol, three glycerol, urea nitrogen, creatinine, uric acid, percentage of neutrophil, 24 hours urinary albumin total (ALBU-24 h) and ALBU were detected.Logistic regression was used to analyze the relationship between DR and various factors, and the risk factors of DR were screened out.
Results
The prevalence of DR inpatients with type 2 diabetes was 28.33%, the prevalence of mild, moderate and severe NPDR were 2.54%, 16.28% and 4.23%, respectively, the prevalence of PDR was 5.29%.The prevalence of DME was 10.36% in the DR patients.The course of diabetes, the levels of serum lipoprotein, creatinine, ALBU-24 h and ALBU were statistically significant between DR group and NDR group (all at P<0.05). By stepwise Logistic regression analysis, the course of disease, FBG were identified as the independent risk factors of DR (course of disease: odds ratio[OR]=1.155, 95% confidence interval[CI]: 1.067-1.251; FBG: OR=1.313, 95%CI: 1.071-1.610).
Conclusions
The course of diabetes, lipoprotein, creatinine, ALBU-24h, ALBU are closely related to the occurrence and development of DR.The course of diabetes and FBG are the independent risk factors of DR.