Anastalsis of triamcinolone acetonide during vitrectomy in proliferative diabetic retinopathy

Authors: Zhou Yanjie,  You Caiyun,  Wang Tian,  Zhang Mingxue,  Song Yinting,  Liao Mengyu,  Han Han,  Zhang Zhuhong,  Li Jianan,  Yan Hua

DOI: 10.3760/cma.j.issn.2095-0160.2017.05.011
Published 2017-05-10
Cite as Chin J Exp Ophthalmol, 2017,35(5): 439-442.

Abstract

Background

Clinical work found that triamcinolone acetonide (TA)bleeding during vitrectomy in proliferative diabetic retinopathy (PDR), but its mechanism is not clear.

Objective

This study was to explore the anastalsis of TA in vitrectomy for PDR.

Methods

A prospective study was performed.Twelve eyes of 12 patients who received vitrectomy combined with the intraocular use of TA for PDR were in cluded in Tianjin Medical University General Hospital from 2011 to 2014 and served as TA group.Thirty-two eyes of 32 patients who underwent vitrectomy for epimacular membrane or macular hole were enrolled as control group.The vitreous specimens of 0.6~0.8 ml was collected during the surgery.The concentrations of urokinase plasminogen activator (u-PA), tissue plasminogen activator (t-PA) and plasminogen activator inhibitors 1 (PAI-1) in vatreous were measured by ELISA.

Results

The mean contents u-PA, t-PA and PAI-1 in the vatreous were 25.45, 127.44 and 0.42 ng/ml respectively in the TA group, and those the mean contents in the control group were 22.94, 142.37 and 0.27 ng/ml respectively, shouwing a significant difference between the TA group and the control group (Z=-2.268, P<0.05). NO significant difference was found in vitreous t-PA and PAI-1 between TA and control groups (Z=-0.092, -1.847, both at P>0.05).

Conclusions

Vitreous u-PA content is increased in PDR eyes, which is more likely to lead bleeding.Anastalsis of TA during vitrectomy for PDR may be relatived to decreasing vitreous t-PA and u-PA contents as well as increasing PAI-1 contents.

Key words:

Proliferative diabetic retinopathy; Triamcinolone acetonide; Urokinase plasminogen activator; Tissue plasminogen activator; Plasminogen activator inhibitors-1

Contributor Information

Zhou Yanjie
Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China
You Caiyun
Wang Tian
Zhang Mingxue
Song Yinting
Liao Mengyu
Han Han
Zhang Zhuhong
Li Jianan
Yan Hua
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Updated: September 4, 2019 — 12:56 pm