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Fluorescein fundus angiography (FFA) is an important examination to observe retinal vascular diseases, but the observation of peripheral retina is limited through traditional FFA.Ultra-widefield fluorescein angiography (UWFA) is a new technique which helps to expand the field of view in retina, and explores peripheral retinopathy clearly.To accurately quantify the retinal non-perfusion area, ischemic index (ISI) was proposed.It is calculated by the ratio of the retinal non-perfusion area to the total retinal area by manual description of non-perfusion area in UWFA images.As a reliable index for evaluating retinal ischemia, it is of great significance to study ISI in the classification, treatment and prognosis of retinal vascular diseases such as diabetic retinopathy (DR) and retinal vein occlusion (RVO). This article reviewed the progress in application and development of ISI in retinal vascular diseases.
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Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China