Application of RNA interference in posterior capsule opacification by interfering signaling pathway

Authors: Xi Yahui,  Liu Hongling

DOI: 10.3760/cma.j.issn.2095-0160.2017.12.014
Published 2017-12-10
Cite as Chin J Exp Ophthalmol, 2017,35(12): 1126-1129.

Abstract

Posterior capsule opacification (PCO) is a common complication after cataract phacoemulsification with intraocular lens (IOL) implantation.The mechanism of lens epithelial cells (LECs) fibrosis, PCO and capsular wrinkle is mainly related with residual LECs migration, proliferation and epithelial-mesenchymal transition (EMT) after cataract surgery.Transforming growth factor β2 (TGF-β2) has been proposed as the most important factor driving the EMT and pathologic fibrosis of LECs, TGF-β2 induces LECs EMT by the Smad signaling pathway.Besides, PI3K/AKT/mTOR signaling pathway was studied to participate in TGF-β2 induced EMT.As one of the gene regulation methods, RNA interference (RNAi) technology shows an important application prospect in inhibiting LECs fibrosis and proliferation by interfering signaling pathway.This review highlights RNAi effects on LECs biological behavior by interfering PI3K/AKT/mTOR and TGF-β2/Smad signaling pathways.

Key words:

Lens epithelial cells; Posterior capsule opacification; RNA interference; Transforming growth factor β2

Contributor Information

Xi Yahui
Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Liu Hongling
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Updated: September 4, 2019 — 2:14 pm