Pyroptosis and eye disease

Authors: Jin Xin,  Zhang Hong

DOI: 10.3760/cma.j.issn.2095-0160.2017.12.015
Published 2017-12-10
Cite as Chin J Exp Ophthalmol, 2017,35(12): 1130-1133.

Abstract

Pyroptosis is a new programmed cell death which has been found recently.Pyroptosis features rapid plasma-membrane rupture and release of pro-inflammatory intracellular contents.Pyroptosis plays a vital role in intracellular bacterial clearance, but may also be involved in the pathological process of inflammatory and autoimmune diseases.It exists in the occurrence, development and dying of many eye diseases.The researches of pyroptosis in age-related macular degeneration(AMD), cataract, dry eye disease, Mooren’s ulcer and acute glaucoma have emerged, an in-depth research may be useful in understanding eye diseases in a deeper level.In this artile, the concept of pyroptosis and its involvement in AMD, cataract, dry eye disease, Mooren’s ulcer and acute glaucoma are reviewed.

Key words:

Pyroptosis; Age-related macular degeneration; Cataract; Dry eye; Mooren’s ulcer; Acute glaucoma

Contributor Information

Jin Xin
the First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin 150006, China
Zhang Hong
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Updated: September 4, 2019 — 2:14 pm