Category: 2017

The efficiency and safety assessment of Entranster™ nanoparticle carrier for CD25 siRNA transfection in rat cornea

Authors:Qin Qin,  Shi Yunjie,  Zhao Min DOI: 10.3760/cma.j.issn.2095-0160.2016.10.005 Published 2016-10-10 Cite as Chin J Exp Ophthalmol, 2016,34(10): 888-895. Abstract Background Gene transfection is an effective therapeutic avenue to target many kinds of eye diseases.Non-viral vectors with high transfection efficiency, long-term expression, low toxicity and high expression levels are pivotal in gene therapy of corneal disease. Objective […]

Comprehensive therapy for retinal artery occlusion

Authors: Li Yifeng,  Wei Wenbin DOI: 10.3760/cma.j.issn.2095-0160.2017.01.020 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 93-96. Abstract Retinal artery occlusion (RAO) is an ocular emergency.Inappropriate therapy results in visual loss.Visual loss caused by RAO occurs as a result of loss of blood supply with the inner retinal layers.We reviewed a number of therapies that have been […]

Application of anti-vascular endothelium growth factor in assisted surgery for proliferative diabetic retinopathy

Authors: Li Bing,  Ye Junjie DOI: 10.3760/cma.j.issn.2095-0160.2017.01.019 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 87-92. Abstract Proliferative diabetic retinopathy (PDR) is one of the serious ocular complications of patients with diabetes mellitus and also the leading cause of blindness.Pars plana vitrectomy (PPV) is an effective treatment for severe vitreous hemorrhage and PDR.The intraocular concentration of […]

Effects of exosomes in pathogenesis of age-related macular degeneration

Authors: Yang Jing,  Chen Song DOI: 10.3760/cma.j.issn.2095-0160.2017.01.018 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 83-86. Abstract Exosomes are nanometer membranous vesicles which can be distributed in a variety of biological fluids, including peripheral blood, urine, saliva and so on.Currently, the multi-step differential centrifugation is a efficient method which can be used to isolate exosomes.Exosomes are […]

Effect of long noncoding RNA on retinal development and ocular diseases

Authors: Wang Bin,  Zhang Yan DOI: 10.3760/cma.j.issn.2095-0160.2017.01.017 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 79-82. Abstract Long noncoding RNAs (lncRNAs) are non-protein coding transcript larger than 200 nucleotides, making up a large fraction of cellular transcripts in mammalian.Recent years have seen a surge of studies aimed at functionally characterizing the role of lncRNAs in development […]

The role of mitochondrial dynamics in retinal ganglion cells

Authors: Hu Xinxin,  Dai Yi DOI: 10.3760/cma.j.issn.2095-0160.2017.01.016 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 74-78. Abstract Mitochondrial dynamics refers to the constant fission, fusion, docking, transportation, and mitophagy of mitochondria within cells.These dynamic processes are not only critical to regulating mitochondrial morphology and function, but also playing key roles in cell survival, metabolism and function.Retinal […]

Preventive effect of intravitreal injection of ranibizumab on rehaemorrhagia following vitrectomy for prolifarative diabetic retinopathy

Authors: Ma Lie,  Li Xiaoxin DOI: 10.3760/cma.j.issn.2095-0160.2017.01.014 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 69-72. Abstract Background Vitrectomy is a primary approach to the treatment of proliferative diabetic retinopathy (PDR). However, postoperative rehaemorrhagia often occur.Ranibizumab is an effective drug of anti-vascular endothelial growth factor, but whether the combination of intravitreal injection of ranibizumab with vitrectomy […]

Relationship of lens advanced glycosylation end products with diabetic retinopathy

Authors: Wang Zhuoshi,  Yang Xiaxia,  Xu Ling,  He Wei DOI: 10.3760/cma.j.issn.2095-0160.2017.01.013 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 64-68. Abstract Background The generation of advanced glycosylation end products (AGEs) is one of the most important characteristics in diabetes mellitus (DM). Its role in diabetic eye disease is still unclear. Objective This study was to investigate the changes […]

Association of thyroid dysfunction with ocular surface damage in thyroid dysfunction patients without thyroid ophthalmopathy

Authors: Zhang Hongjuan,  Zhang Zuncheng,  Mao Chunjie DOI: 10.3760/cma.j.issn.2095-0160.2017.01.012 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 58-63. Abstract Background It is determined that the patients with thyroid-associated ophthalmopathy (TAO) often occur dry-eye related symptoms due to increasing tear evaporation caused by exophthalmos.However, more than half of thyroid dysfunction patients without TAO appear ocular surface inflammation.It is […]

Imaging performance and quantitative analysis of confocal scanning laser ophthalmoscope for cystoid macular edema

Authors: Huo Yanjiao,  Yang Lihong,  Wei Wenbin DOI: 10.3760/cma.j.issn.2095-0160.2017.01.011 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 53-57. Abstract Background Cystoid macular edema (CME) is caused by many fundus diseases.The noninvasive clinical diagnosis methods for CME are conventional color fundus photography up to now.However, these images can not display the CME range well.Confocal scanning laser ophthalmoscope (cSLO) […]