Authors: Qin Xiuhong, Sun Xiaojing, Lu Jianmin DOI: 10.3760/cma.j.issn.2095-0160.2018.07.018 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 570-575. Abstract [Download PDF] [Read Full Text] Infectious keratitis is one of the leading causes of irreversible vision loss.With the emergence of multidrug-resistant pathogen, despite appropriate diagnosis and antimicrobial treatment, […]
Category: 2018, No. 07
Role of CD160/BTLA-HVEM-LIGHT/LT-α signaling pathway related to herpetic stromal keratitis
Authors: Tan Tianchang, Xia Likun DOI: 10.3760/cma.j.issn.2095-0160.2018.07.017 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 564-569. Abstract [Download PDF] [Read Full Text] Ocular infection of herpes simplex virus-1 (HSV1) can result in herpetic stromal keratitis (HSK), which impairs vision and is a common cause of human […]
Research progress in Bietti crystalline corneoretinal dystrophy
Authors: Zhang Zhimeng, Li Genlin DOI: 10.3760/cma.j.issn.2095-0160.2018.07.016 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 559-563. Abstract [Download PDF] [Read Full Text] Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessive retinal degenerative disease characterized by crystalline deposits in the retina, followed by progressive atrophy of […]
Application of CRISPR/Cas9 genome editing technology in the research of eye diseases
Authors: Fan Xiangyu, Xu Jianjiang DOI: 10.3760/cma.j.issn.2095-0160.2018.07.015 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 553-558. Abstract [Download PDF] [Read Full Text] The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) is an adaptive immune system against invasive viruses and exogenous DNA, which is developed […]
Studies on pathogenesis and gene therapy of red-green color blindness
Authors: Xu Fan, Pang Jijing DOI: 10.3760/cma.j.issn.2095-0160.2018.07.014 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 549-552. Abstract [Download PDF] [Read Full Text] Red-green color blindness is the most common form of colour blindness.Traditional treatment options such as tinted lenses do not cure color blindness completely.With the […]
Analysis of the genotype and phenotye in 3 pedigrees with Stargardt disease
Authors: Rong Weining, Ma Runqing, Fang Xinhe, Sheng Xunlun DOI: 10.3760/cma.j.issn.2095-0160.2018.07.013 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 544-548. Abstract [Download PDF] [Read Full Text] Objective To analyze the relationship between genotype and phenotype in 3 pedigrees with Stargardt disease. Methods Three pedigrees with Stargardt disease were […]
NDP gene variants analysis and clinical features of Norrie disease and familial exudative vitreoretinopathy
Authors: You Bing, Xu Ke, Sun Tengyang, Zhang Xiaohui, Xie Yue, Li Yang DOI: 10.3760/cma.j.issn.2095-0160.2018.07.012 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 539-543. Abstract [Download PDF] [Read Full Text] Objective To analyze the clinical features and NDP gene variants in patients with Norrie disease and familial exudative vitreoretinopathy, (FEVR). […]
The screening of pathogenic locus in a primary open angle glaucoma pedigree
Authors: Wang Junfang, Ma Wenjiang, Lin Ying, Yang Zhenglin DOI: 10.3760/cma.j.issn.2095-0160.2018.07.010 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 533-536. Abstract [Download PDF] [Read Full Text] Objective To screen the pathogenic locus and gene in a primary open angle glaucoma(POAG), and to provide a basis for molecular genetic […]
Compound heterozygous mutations of CRB1 gene in a Chinese family with Leber congenital amaurosis by whole exome sequencing
Authors: Cao Yingjie, Xiao Xiaoqiang, Chen Shaowan, Zheng Yuqian, Chen Haoyu DOI: 10.3760/cma.j.issn.2095-0160.2018.07.008 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 526-530. Abstract [Download PDF] [Read Full Text] Objective To investigate the disease-causing mutation in a family with Leber congenital amaurosis (LCA). Methods A Chinese […]
Study of natural history of Chinese patients with choroideremia
Authors: Han Xiaoxu, Li Hui, Wu Shijing, Sun Zixi, Zhou Qi, Sui Ruifang DOI: 10.3760/cma.j.issn.2095-0160.2018.07.007 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 519-525. Abstract [Download PDF] [Read Full Text] Objective To provide detailed clinical and molecular genetic findings and describe the characteristics of natural history in Chinese choroideremia (CHM) […]