Authors: Fang Mengyuan, Li Qiuming, Yang Xin, Wan Weiwei, Long Yang, Liu Hongzhuo, Wan Wencui DOI: 10.3760/cma.j.cn115989-20201024-00713 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 593-601. Abstract [View PDF] [Read Full Text] Objective To investigate the protective effect of asiatic acid (AA) on blood-retinal […]
Category: Experimental Science
Research on screening system of myopic maculopathy based on deep convolution neural network
Authors: Shi Chunsheng, Liu Lei, Wang Yaru, Wang Zefei DOI: 10.3760/cma.j.cn115989-20191115-00495 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 602-608. Abstract [View PDF] [Read Full Text] Objective To develop a fully automatic detection system based on the deep convolution neural network (DCNN) for screening […]
Inhibiting effect of retinal Sigma-1 receptor antagonist on the form deprivation myopia in guinea pigs and its mechanism
Authors: Chen Yuanyuan, Xie Fujuan, Li Haibo, Guan Yuxin, Mao Junfeng DOI: 10.3760/cma.j.cn115989-20200615-00433 Published 2021-06-10 Cite asChin J Exp Ophthalmol, 2021, 39(6): 477-482. Abstract [View PDF] [Read Full Text] Objective To investigate the role and mechanism of retinal Sigma-1 receptor antagonist N, N-diethyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethanaminehydrochloride (NE-100) in […]
Relationship between irradiation time of riboflavin-ultraviolet A scleral collagen cross-linking and retinal injury
Authors: Yan Dong, Liu Limei, Ming Chunxiu, Zhang Shaobin DOI: 10.3760/cma.j.cn115989-20190703-00287 Published 2021-06-10 Cite asChin J Exp Ophthalmol, 2021, 39(6): 483-489. Abstract [View PDF] [Read Full Text] Objective To investigate the effects of riboflavin-ultraviolet A scleral collagen cross-linking on the retina under different irradiation time, […]
All-trans retinoic acid-induced apoptosis signaling pathway in ARPE-19 cells
Authors: Wu Juan, Cui Dongmei, Yang Xiao, Zeng Junwen DOI: 10.3760/cma.j.cn115989-20190704-00293 Published 2021-06-10 Cite asChin J Exp Ophthalmol, 2021, 39(6): 490-497. Abstract [View PDF] [Read Full Text] Objective To investigate all-trans retinoic acid(ATRA)-induced apoptosis signaling pathway in ARPE-19 cells in vitro. Methods The APRE-19 cell […]
Label-free quantitative proteomic analysis of aqueous humor in patients with high myopia
Authors: Xue Min, Ren Xinjun, Ke Yifeng, Liu Juping, Fan Xiaoe, Li Xiaorong DOI: 10.3760/cma.j.cn115989-20200716-00503 Published 2021-06-10 Cite asChin J Exp Ophthalmol, 2021, 39(6): 498-504. Abstract [View PDF] [Read Full Text] Objective To characterize proteomic profile in aqueous humor of patients with high myopia using […]
Transcriptomics analysis of hypoxia-induced retinal pigment epithelium cell injury
Authors: Lu Cong, Shi Pingling, Yang Qixiang, Song Hao, Li Miao, Zhang Beibei, Song Zongming DOI: 10.3760/cma.j.cn115989-20201127-00799 Published 2021-06-10 Cite asChin J Exp Ophthalmol, 2021, 39(6): 505-514. Abstract [View PDF] [Read Full Text] Objective To analyze differentially expressed genes (DEGs) and the changes of signal […]
Proteomics analysis of mouse lens supernatant treated with hydrogen peroxide in vitro
Authors: Li Guo, Chen Ying, Yan Hong, Zhou Xiyuan DOI: 10.3760/cma.j.cn115989-20200730-00546 Published 2021-05-10 Cite asChin J Exp Ophthalmol, 2021, 39(5): 382-387. Abstract [View PDF] [Read Full Text] Objective To study the protein leakage of mouse lens treated with hydrogen peroxide in vitro, and to identify […]
Construction of Crx-iCreERT2 fluorescent reporter human embryonic stem cells by CRISPR/Cas9 technology and 3D retinal organoid culture
Authors: Du Yuxin, Liu Yizong, Yan Feiyue, Shen Yin DOI: 10.3760/cma.j.cn115989-20210208-00103 Published 2021-05-10 Cite asChin J Exp Ophthalmol, 2021, 39(5): 388-397. Abstract [View PDF] [Read Full Text] Objective To establish Crx-iCreERT2 fluorescent reporter human embryonic stem cell lines using CRISPR/Cas9 technology and 3D retinal organoid […]
Inhibitory effect of miR-146a on high glucose-induced apoptosis of retinal microvascular endothelial cells and its mechanism
Authors: Gao Fei, Wu Zhipeng, Ruan Yihua DOI: 10.3760/cma.j.cn115989-20190703-00286 Published 2021-05-10 Cite asChin J Exp Ophthalmol, 2021, 39(5): 398-403. Abstract [View PDF] [Read Full Text] Objective To investigate the effect of microRNA-146a (miR-146a) on apoptosis of human retinal microvascular endothelial cells (HRMECs) induced by high […]