Category: Experimental Science

Establishment of lens opacity model in Grx2 knockout mice based on CRISPR/cas9 system and the role of Grx2 in the pathogenesis of cataract

Authors: Guo Yong,  Guo Chenjun,  Zhang Jie,  Ning Xiaona,  Chen Xi,  Yan Hong DOI: 10.3760/cma.j.cn115989-20210308-00149 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 894-901. Abstract                                       [View PDF] [Read Full Text] Objective              […]

Classification of adenoviral conjunctivitis based on sequencing and phylogenetic analysis of hexon and fiber

Authors: Wang Jing,  Zhu Jianfeng,  Lu Lina DOI: 10.3760/cma.j.cn115989-20200430-00300 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 902-907. Abstract                                       [View PDF] [Read Full Text]  Objective To classify human adenovirus (HAdV) of adenoviral conjunctivitis by sequencing and […]

Protective effect of tert-butylhydroquinone on retinal morphology and function in early diabetic rats and its mechanism

Authors: Wang Juan,  Wei Fang,  Cao Yang,  Tian Min,  Lyu Hongbin DOI: 10.3760/cma.j.cn115989-20191225-00555 Published 2022-09-10 Cite asChin J Exp Ophthalmol, 2022, 40(9): 796-803. Abstract                                       [View PDF] [Read Full Text] Objective To investigate the protective effects of an […]

Inhibitory effect of microRNA-23b-3p on high glucose-induced autophagy and apoptosis of human lens epithelial cells and its mechanism

·Experimental Research· Role and mechanism of microRNA-23b-3p in regulating high glucose-induced autophagy and apoptosis of human lens epithelial cells Liu Wenlan, Wang Li, Yang Yang, Yan Jin School of Medical Technology, Xi’an Medical University, Xi’an 710021, China Corresponding author: Wang Li, Email: 63148645@qq.com [Abstract]                        […]

Network pharmacology analysis of ginkgo leaves extract against diabetic retinopathy

·Experimental Research· Network pharmacology analysis of ginkgo leaf extract against diabetic retinopathy Bai Wen, Jiang Qin Eye Hospital, Nanjing Medical University, Nanjing 210029, China Corresponding author: Jiang Qin, Email: jqin710@vip.sina.com [Abstract]                   [View PDF in English] [View PDF in Chinese] [Read Full Text] Objective  To identify the key […]

Meibomian gland dysfunction and expressions of inflammatory factors and lipid metabolic factors in diabetic mice

·Experimental research· Meibomian gland dysfunction and expressions of inflammatory factors and lipid metabolic factors in diabetic mice Zou Yuanyuan, Liu Xuemei, Qi Yuanyuan, Zhao Shaozhen Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin […]

Therapeutic effect of anti-IL-12/IL-23 p40 on experimental autoimmune uveitis and its mechanism

·Experimental Research· Therapeutic effect of anti-IL-12/IL-23 p40 on experimental autoimmune uveitis and associated mechanism Cui Xuexue, Zhang Zhihui, Wu Lingzi, Li Yongtao, Chen Shuang, Chen Nu, Zhang Xiaomin Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University […]

Immunoregulatory effects of miR-31-5p overexpression on peripheral blood Th17 cell in a rabbit model of autoimmune dry eye

Authors: Gao Min,  Zhao Lu,  Chen Sisi,  Wei Ruihua,  Nian Hong DOI: 10.3760/cma.j.cn115989-20210809-00452 Published 2022-08-10 Cite asChin J Exp Ophthalmol, 2022, 40(8): 716-723. Abstract                                       [View PDF] [Read Full Text] Objective To investigate the immunoregulatory effects of lentivirus-mediated microRNA (miR)-31-5p overexpression on peripheral […]

Inhibitory effect of RMT1-10-induced tolerogenic dendritic cells in vitro on high-risk corneal allograft rejection in mice and its mechanism

Authors: Zhao Min,  Yang Liuqing,  Wang Mengyu,  Tao Yu,  Guo Yongyue,  Su Ruifeng,  Shi Jing,  Tan Xiaobo DOI: 10.3760/cma.j.cn115989-20201228-00868 Published 2022-08-10 Cite asChin J Exp Ophthalmol, 2022, 40(8): 725-733. Abstract                                       [View PDF] [Read Full Text] Objective To investigate the inhibitory effect of […]

Inhibitory effect of vorinostat encapsulated hydroxypropyl-β-cyclodextrin eye drops on corneal neovascularization induced by alkali burns in mouse

Authors: Yang Jingjing,  Liang Zhen,  Lu Ping,  Zhang Zhen,  Zhang Junjie DOI: 10.3760/cma.j.cn115989-20200807-00566 Published 2022-07-10 Cite asChin J Exp Ophthalmol, 2022, 40(7): 609-616. Abstract                                       [View PDF] [Read Full Text] Objective To prepare vorinostat encapsulated hydroxypropyl-β-cyclodextrin (SAHA-CD) eye drops and investigate its inhibitory […]