Category: Experimental Science

Preparation and drug release effect evaluation of drug-loaded cross-linked decellularized corneal stromal lenticules in vitro

Authors: Rao Jing,  Chen Jiansu,  Gu Jianing,  Chen Xiao,  Wang Yini,  Liu Yonghuan,  Pu Aijun,  Zhou Qizhi DOI: 10.3760/cma.j.cn115989-20190817-00353 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1004-1010. Abstract Objective To prepare a drug release system of drug-loaded cross-linked decellularized corneal stromal lenticules and evaluate its drug release characteristics in vitro. Methods Lenticules were […]

Network pharmacology analysis of metformin against diabetic retinopathy

Authors: Chen Yuan,  Xing Qian,  Huang Zhengru DOI: 10.3760/cma.j.cn115989-20191215-00543 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1011-1015. Abstract Objective To explore the pharmacological molecular mechanisms of metformin against diabetic retinopathy (DR) based on network pharmacology approach. Methods After chemical constitution of metformin was acquired from Pubchem database, target genes of metformin were identified […]

Anti-apoptosis and anti-inflammation effects and mechanism of berberine on high-concentration glucose induced rat retinal Müller cells

Authors: Jin Yiping,  Zhu Haohao,  Liao Yujie,  Yu Xiaoyan DOI: 10.3760/cma.j.cn115989-20200917-00647 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1016-1024. Abstract Objective To investigate the effects of berberine on Sprague Dawley (SD) rat retinal Müller cells cultured by high concentration glucose. Methods The cultured SD rat retinal Müller cells were divided into normal-glucose group, […]

Protective effect and mechanism of esculetin on oxidative damaged ARPE-19 cells

Authors: Zhang Yingjun,  Bai Ge,  He Xiangdong,  Zhang Donglei,  He Wei DOI: 10.3760/cma.j.cn115989-20200224-00101 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1025-1031. Abstract Objective To study the protective effect and the mechanism of esculetin on oxidative-stressed human retinal pigment epithelial cells (ARPE-19) induced by tert-butyl hydroperoxide (t-BHP). Methods The ARPE-19 cells were divided into […]

Ocular pharmacokinetics of econazole solid lipid nanoparticle eye drops after single dose topical administration in rabbits

Authors: Liang Zhen,  Zhang Zhen,  Li Jingguo,  Yang Jingjing,  Lu Ping,  Zhou Tianyang,  Zhang Junjie DOI: 10.3760/cma.j.cn115989-20191008-00429 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1032-1037. Abstract Objective To investigate the pharmacokinetics of econazole solid lipid nanoparticles (E-SLNs) after administration of one single dose in rabbit eyes. Methods E-SLNs with 0.2% econazole was prepared […]

Ocular pharmacokinetics of topical administration of butenafine nanomicelles in rabbit eyes

Authors: Lu Ping,  Liang Zhen,  Zhang Zhen,  Yang Jingjing,  Song Fei,  Li Jingguo,  Zhou Tianyang,  Zhang Junjie DOI: 10.3760/cma.j.cn115989-20200526-00374 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1038-1044. Abstract Objective To study the pharmacokinetics of the broad-spectrum antifungal drug butenafine nanomicelles (BTF-NM) after topical instillation. Methods The self-assembly method was used to prepare BTF-NM.The […]

Stability evaluation of different internal fixation methods for zygomaticomaxillary complex fractures by finite element biomechanical analysis

Authors: Li Yan,  Wu Pengsen,  Ma Yue,  Tang Meiting,  Zeng Xueying,  Tang Yuanyuan,  Yu Shen,  Lu Wei DOI: 10.3760/cma.j.cn115989-20200727-00529 Published 2020-11-10 Cite as Chin J Exp Ophthalmol, 2020,38(11): 916-922. Abstract Objective To analyze the stability of different internal fixation methods for zygomaticomaxillary complex fracture using finite element biomechanical analysis and to provide a quantitative basis […]

Effects of IL-17A and IFN-γ on the fibrosis of CD34- orbital fibroblasts in Graves orbitopathy

Authors: Lu Yi,  Huang Yazhuo,  Li Yinwei,  Wu Yu,  Fang Sijie,  Sun Jing,  Zhou Huifang DOI: 10.3760/cma.j.cn115989-20200719-00513 Published 2020-11-10 Cite as Chin J Exp Ophthalmol, 2020,38(11): 923-928. Abstract Objective To observe the effects of interleukin-17A (IL-17A) and interferon-γ (IFN-γ) on CD34– orbital fibroblasts (OFs) in patients with Graves ophthalmopathy (GO), and to explore the pathogenesis […]

Inhibitory effects of resveratrol on high glucose-induced apoptosis of retinal cells

Authors: Li Qingchun,  Li Dai,  Xing Yiqiao DOI: 10.3760/cma.j.cn115989-20200519-00351 Published 2020-11-10 Cite as Chin J Exp Ophthalmol, 2020,38(11): 929-935. Abstract Objective To investigate the inhibitory effects of resveratrol (Res) on the apoptosis of retinal neurons of diabetic rats and ARPE-19 cells induced by high glucose. Methods Streptozotocin was intraperitoneally injected to establish a diabetes model […]

Effects of early applying basic fibroblast growth factor on corneal haze after surface ablation surgery and its mechanism

Authors: Sui Wenjun,  Gao Honglian,  Liu Qiqi,  Zhang Lei DOI: 10.3760/cma.j.cn115989-20190418-00190 Published 2020-11-10 Cite as Chin J Exp Ophthalmol, 2020,38(11): 936-943. Abstract Objective To investigate the effects of early applying of basic fibroblast growth factor (bFGF) on corneal haze formation after surface ablation surgery in rabbits. Methods The right eyes of 60 healthy New Zealand […]