Category: Experimental Science

Effect of ROS/NLRP3/Caspase-1 signaling pathway on the apoptosis of retinal pigment epithelial cells induced by high glucose

Authors: Li Hongsong,  Li Rong,  Wang Lijun,  Liao Dingying,  Wang Jianming DOI: 10.3760/cma.j.cn115989-20210420-00267-1 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 6-12. Abstract Objective To investigate the effect of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 (NLRP3) inflammasome on the proliferation and apoptosis of human retinal pigment epithelial cell line ARPE-19 exposed to […]

Proteomic analysis of optic nerve in the rat model of non-arteritic anterior ischemic optic neuropathy

Authors: Hu Liying,  Li Zhiqing,  Shao Xianfeng,  Guo Xiaoxue,  Yu Dawei,  Dong Lijie,  Li Xiaorong DOI: 10.3760/cma.j.cn115989-20201104-00745 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 13-20. Abstract Objective To quantitatively analyze the protein expression changes of the optic nerve in an SD rat model of non-arteritic anterior ischemic optic neuropathy (NAION), and to make […]

Effect of human umbilical cord derived mesenchymal stem cells on apoptosis of rat retinal ganglion cells under high glucose and on the regulation of p38MAPK pathway

Authors: Liu Xi,  Sun Xiaoping,  Yang Jianwei,  Zhu Dongmei,  Wang Yuan DOI: 10.3760/cma.j.cn115989-20200804-00559 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 21-28. Abstract Objective To investigate the effect of human umbilical cord mesenchymal stem cells (hUC-MSC) on the apoptosis of retinal ganglion cells (RGCs) in diabetic retinopathy (DR) model rats and on the regulation […]

Expression and significance of Jagged1 in fibrovascular membranes of proliferative diabetic retinopathy

Authors: Guo Qingmin,  Meng Xuxia,  Yang Kun,  Yu Chuan DOI: 10.3760/cma.j.cn115989-20191018-00453 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 29-34. Abstract Objective To observe the expression and significance of Jagged1 in fibrovascular membranes of proliferative diabetic retinopathy (PDR). Methods Sixty preretinal fibrovascular membrane specimens collected from fifty-seven patients (60 eyes) with PDR during vitrectomy […]

Feasibility of cryopreservation of human corneal stromal lenticules

Authors: Wei Qi,  Ding Hui,  Zhong Tan,  Yu Hanyang,  Yang Zhenduo,  Fan Hongming,  He Linyi,  Zhong Xingwu DOI: 10.3760/cma.j.cn115989-20210413-00249 Published 2021-12-10 Cite asChin J Exp Ophthalmol, 2021, 39(12): 1031-1037. Abstract Objective To observe the transparency and tissue structure changes of human corneal stromal lenticules after long-term cryopreservation and explore a simple and feasible method for […]

Pathological study of the levator palpebrae superioris muscle in patients with different severities of simple congenital ptosis

Authors: Luo Yanzhu,  Li Dongping,  Zhou Na,  Li Junping,  Wang Yuhong DOI: 10.3760/cma.j.cn115989-20200917-00653 Published 2021-12-10 Cite asChin J Exp Ophthalmol, 2021, 39(12): 1038-1045. Abstract Objective To observe the pathological changes of levator palpebrae superiors muscle in patients with different severities of simple congenital ptosis (SCP). Methods Levator palpebrae superiors muscle specimens from 102 eyes of […]

Effect of integrin ανβ3 on conjunctival scar formation after glaucoma filtration surgery in rats

Authors: Zhu Xiaoyan,  Xie Lin,  Tan Wei DOI: 10.3760/cma.j.cn115989-20190917-00398 Published 2021-12-10 Cite asChin J Exp Ophthalmol, 2021, 39(12): 1046-1052. Abstract Objective To investigate the expression of integrin ανβ3 in conjunctival scar after glaucoma filtration surgery and to explore its role in the formation of filtering scar in rats. Methods Fifty-five SPF male SD rats aged […]

Enhanced effect of microRNA-338-3p in bone marrow-derived dendritic cells on IRBP1-20-specific T helper 17 cells activation in experimental autoimmune uveitis

Authors: Yang Chao,  Wei Yankai,  Wei Ruihua,  Nian Hong DOI: 10.3760/cma.j.cn115989-20200608-00404 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 933-939. Abstract Objective To investigate the role of microRNA-338-3p (miR-338-3p) in regulating the generation and function of interphotoreceptor retinoid-binding protein (IRBP)1-20-specific T helper 17 (Th17) cells in experimental autoimmune uveitis (EAU). Methods Bone marrow cells […]

Inhibitory effect of rosmarinic acid on high glucose-induced angiogenesis of human retinal microvascular endothelial cells and the activation of NLRP3 inflammasome pathway

Authors: Fan Jiangli,  Guan Yanling,  Li Rong,  Yao Yang DOI: 10.3760/cma.j.cn115989-20191203-00520 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 940-948. Abstract Objective To investigate the inhibitory effects of rosmarinic acid (RA) on high glucose-induced angiogenesis of human retinal microvascular endothelial cells (HRMEC) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway-related proteins. Methods […]

Effects of intravenous injection of human umbilical cord mesenchymal stem cells-derived small extracellular vesicles on experimental autoimmune uveitis in mice

Authors: Li Yongtao,  Duan Yanan,  Li Huan,  Zhang Zhihui,  Ren Xinjun,  Li Xiaorong,  Zhang Xiaomin DOI: 10.3760/cma.j.cn115989-20200430-00302 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 949-956. Abstract Objective To explore the therapeutic effects of intravenous injection of small extracellular vesicles (sEVs) derived from human umbilical cord mesenchymal stem cells (MSCs) on experimental autoimmune uveitis […]