Authors:Fan Yuanyuan,Luo Yufan, Xie Ping, Hu Zizhong Corresponding author: Hu Zizhong, Email: huzizhong@njmu.edu.cn Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260427-00191 ABSTRACT Objective To construct engineered exosomes loaded with the p300 inhibitor A485 (A485@EV) and to investigate their effects and mechanisms in inhibiting hypoxia-induced pathological neovascularization by targeting inhibition of lactylation. Methods A485@EV was prepared by sonication, and its markers, morphology and physical and chemical properties […]
Category: Experimental Science
Ameliorative effect of acteoside on high glucose-induced oxidative stress and mitochondrial damage by modulating SIRT1-mediated mitophagy in RPE cells
Authors: Shen Shuhong, Li Yan, Ma Jia, Chen Qianbo, Xi Xiaoting Corresponding author: Xi Xiaoting, Email:xi_xiao_ting@163.com Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260330-00144 ABSTRACT Objective To investigate the regulatory effect and molecular mechanism of acteoside on oxidative stress and mitochondrial damage in high glucose-induced human retinal pigment epithelial cells (ARPE-19). Methods ARPE-19 cells were divided into normal control group, mannitol group, high-glucose group, high-glucose+Mito-TEMPO (reactive oxygen […]
Accuracy and repeatability of fluorescence PCR for detecting TGFBI gene mutation in corneal dystrophy
Authors:Sun Xiuli, Gu Yixuan, Zhu Lei,Tian Lei, Wang Yinghui,Jie Ying Corresponding author:Jie Ying, Email:jie_yingcn@aliyun.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20250916-00300 ABSTRACT Objective To evaluate the accuracy and repeatability of fluorescence PCR in detecting TGFBI gene mutation in patients with corneal dystrophy. Methods ARMS-PCR combined with TaqMan probe method was used for genotyping the R124H, R124C, R555W, and R555Q loci (covering heterozygous and homozygous mutation) in the TGFBI gene in peripheral […]
Effect and mechanism of haptoglobin regulating retinal vascular barrier and mediating inflammatory response in diabetic macular edema
Authors:Zhang Yue, Li Jiayu, Zhai Xinran, Yao Yao, Li Liyan, Xiao Zhe, Chen Han, Pang Wu, Yang Zanzhang, Zhang Minglian Corresponding author:Zhang Minglian, Email:zhmlyk@163.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20250521-00166 ABSTRACT Objective To investigate the role and mechanism of haptoglobin (HP) in regulating retinal vascular barrier function and inflammatory response in diabetic macular edema (DME). Methods Aqueous humor samples were collected from 7 patients with non-proliferative diabetic retinopathy (NPDR) and […]
Inhibitory effect and mechanism of SB225002 on NLRP3 inflammasome in retinal vascular endothelial cells under high glucose
Authors:Wang Qing, Zhuang Tongtong, Dong Lijie,Wang Linni Corresponding author:Wang Linni, Email:wln5156@163.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20250609-00190 ABSTRACT Objective To observe the effect and possible mechanism of interleukin (IL)-8 antagonist SB225002 on the activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in monkey retinal vascular endothelial cells (RF/6A cells) under high glucose conditions. Methods The RF/6A cells cultured in vitro were […]
Preventive and protective effects of guanethidine against MRSA endophthalmitis in rabbits
Authors:Liang Qian, Shao Zheng,Fan Zheng, Wang Weina, Huang Yusen Corresponding author:Huang Yusen, Email:huang_yusen@126.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240612-00150 ABSTRACT Objective To establish a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA) endophthalmitis and to investigate the regulatory effects of the sympatholytic agent guanethidine on the inflammatory response in endophthalmitis. Methods Six male New Zealand white rabbits of about 2.5 kg were selected and […]
Effect of miR-655-3p targeting FOXC1 and CXCR4 on angiogenesis in hypoxic human umbilical vein endothelial cells
Authors: Yang Lingqi, Li Jianfeng, Yang Hongxia, Wang Xue, Lyu Yang Published: 2026 -06 -10 DOI: 10.3760/cma.j.cn115989-20240715-00194 Citation Yang Lingqi, Li Jianfeng, Yang Hongxia, et al. Effect of miR-655-3p targeting FOXC1 and CXCR4 on angiogenesis in hypoxic human umbilical vein endothelial cells[J]. Chin J Exp Ophthalmol, 2026, 44(6):521-530. DOI: 10.3760/cma.j.cn115989-20240715-00194. ABSTRACT […]
In vitro study on corneal biomechanical changes after corneal stromal lenticule implantation combined with corneal collagen cross-linking
Authors: Shen Di, Zhang Na, Sun Xiyu, Wei Wei DOI: 10.3760/cma.j.cn115989-20260121-00038 Published: 2026 -05 -10 Citation Shen Di, Zhang Na, Sun Xiyu, et al . In vitro study on corneal biomechanical changes after corneal stromal lenticule implantation combined with corneal collagen cross-linking[J]. Chin J Exp Ophthalmol, 2026, 44(5):439-446. DOI: 10.3760/cma.j.cn115989-20260121-00038. ABSTRACT […]
Effect of high-fat diet on refractive development and ocular biological characteristics in guinea pigs
Authors: Zhang Xiaoran, Chen Yamin, Zhang Ning, Luan Zichen, Hao Rui DOI: 10.3760/cma.j.cn115989-20250901-00283 Published: 2026 -04 -10 Citation Zhang Xiaoran, Chen Yamin, Zhang Ning, et al. Effect of high-fat diet on refractive development and ocular biological characteristics in guinea pigs[J]. Chin J Exp Ophthalmol, 2026, 44(4):331-338. DOI: 10.3760/cma.j.cn115989-20250901-00283. ABSTRACT [Download […]
Construction of a mouse defocus myopia model based on an anti-scratch device and changes in ocular OCT parameters
Authors: Qin Zhuozhen, Fang Yan, Xie Chi, Zhu Shaojin, Ding Liang, Pan Zhongcen DOI: 10.3760/cma.j.cn115989-20250408-00113 Published: 2026 -04 -10 Citation Qin Zhuozhen, Fang Yan, Xie Chi, et al. Construction of a mouse defocus myopia model based on an anti-scratch device and changes in ocular OCT parameters[J]. Chin J Exp Ophthalmol, 2026, 44(4):339-345. DOI: 10.3760/cma.j.cn115989-20250408-00113. ABSTRACT […]