Category: Experimental Science

Establishment and evaluation of a novel retinal ischemia-reperfusion injury model

Authors: Wen Xin,  Yuan Miner,  Li Cheng,  Zeng Jieting,  Lin Xiaofeng DOI: 10.3760/cma.j.cn115989-20190404-00162 Published 2020-07-10 Cite as Chin J Exp Ophthalmol, 2020,38(07): 566-572. Abstract Objective To explore the feasibility to establish a novel retinal ischemia reperfusion (RIR) injury model by applying pars plana vitrectomy (PPV) combined with retinal vascular counterpulsation in the central retinal artery occlusion […]

Safe dose of 650 nm low-power semiconductor laser irradiation in chicken retina

Authors: Wang Yipeng,  Chen Song,  Yang Wenchao,  Kong Jiahui DOI: 10.3760/cma.j.cn115989-20200519-00359 Published 2020-07-10 Cite as Chin J Exp Ophthalmol, 2020,38(07): 573-580. Abstract Objective To observe whether there was a chronic light damage after the irradiation of 650 nm semiconductor laser (power 2 mW) in chicken cone-rich-retina and discuss the safety of this laser for retina. Methods […]

Inhibiting effect of subconjuctivally injected conbercept on experimental corneal neovascularization and lymphangiogenesis in rabbit

Authors: Chen Xiaoxia,  Li Jing,  Gu Zhencheng DOI: 10.3760/cma.j.cn115989-20190327-00149 Published 2020-07-10 Cite as Chin J Exp Ophthalmol, 2020,38(07): 581-588. Abstract Objective To investigate the value of conbercept in experimental corneal nevascularization (CNV) and lymphangiogenesis in rabbit model. Methods Forty-four adult New Zealand rabbits were randomly divided into a conbercept injected group (9 rabbits), a ranibizumab injected […]

Protective effect of astaxanthin on the retinopathy of type 1 diabetic rats

Authors: Yang Ming,  Zhao Tong,  Deng Tingting,  Pan Lin,  Wang Zhijun DOI: 10.3760/cma.j.cn115989-20200519-00360 Published 2020-07-10 Cite as Chin J Exp Ophthalmol, 2020,38(07): 589-596. Abstract Objective To investigate the protective effect of astaxanthin on the retinopathy in rats with type 1 diabetes and related mechanism. Methods Thirty-six male SPF rats received intraperitoneal injection of 1% streptozotocin (STZ) […]

Effect of leukocyte common antigen-related phosphatase receptors on the regulation of visual plasticity in rats

Authors: Xie Laiqing,  Xu Guoxu,  Ni Yong,  Zhang Ji,  Ji Xiaoyan,  Lou Hui,  Song E DOI: 10.3760/cma.j.cn115989-20190617-00265 Published 2020-06-10 Cite as Chin J Exp Ophthalmol, 2020,38(06): 476-481. Abstract Objective To investigate the effects of leukocyte common antigen-related phosphatase receptor (LAR) on the regulation of visual plasticity in rats. Methods Fourty newborn Wistar rats were randomly divided […]

Ultrastructural and biomechanical characteristics of internal limiting membrane in high myopic macular hole

Authors: Chen Lu,  Wei Yantao,  Fang Dong,  Zhang Zhaotian,  Zhang Ting,  Jiang Xintong,  Zhang Shaochong DOI: 10.3760/cma.j.cn115989-20190612-00257 Published 2020-06-10 Cite as Chin J Exp Ophthalmol, 2020,38(06): 482-487. Abstract Objective To investigate the ultrastructural and biomechanical properties of the internal limiting membrane (ILM) in high myopic macular hole (HM-MH) eyes. Methods ILM specimens were peeled from 14 […]

Tropisms of rAAV2, 6, 8, 9 serotypes for intravitreal injection in the mouse retina

Authors: Li Taiming,  Wei Zheng,  Liu Xiaomei,  Shao Jiahong,  Yuan Yun,  Cao Jinjing,  Wang Feifei,  Wang Dongxin,  Li Wensheng,  Zhang Chun DOI: 10.3760/cma.j.cn115989-20200326-00210 Published 2020-05-10 Cite as Chin J Exp Ophthalmol, 2020,38(05): 381-387. Abstract Objective To compare the tropism of different adeno-associated virus (AAV) serotypes in retinal cells. Methods The plasmids pFastBacDual-inCap and pFastBacDual-ITR-CMV-EGFP were constructed […]

Difference in cell biological behavior and ultraviolet radiation effect between double-head and unilateral pterygium fibroblasts cultured in vitro

Authors: Peng Juan,  Mao Yan,  Yao Daqiang,  Dong Shuting,  Sha Xiangyin DOI: 10.3760/cma.j.cn115989-20200326-00211 Published 2020-05-10 Cite as Chin J Exp Ophthalmol, 2020,38(05): 388-394. Abstract Objective To explore the difference in the proliferation, migration and ultraviolet radiation effect between double-head and unilateral pterygium fibroblasts (HPFs) cultured in vitro. Methods Pterygium tissue was obtained from patients who underwent pterygium […]

Inhibitory effect and biological mechanism of Dickkopf-1 on the proliferation of human lens epithelial cells

Authors: Zhang Limin,  Bao Xiuli DOI: 10.3760/cma.j.cn.115985-20190328-00151 Published 2020-04-10 Cite as Chin J Exp Ophthalmol, 2020,38(04): 285-290. Abstract Objective To investigate the effects of Dickkopf-1(DKK1) on the proliferation of human lens epithelial cells (LECs) and its possible mechanism in order to search a new target for the treatment of posterior capsular opacification (PCO). Methods Human LECs […]

Changes in DNA methylation of retinal gene promoter regions and their significance in type 1 diabetic rats

Authors: Li Yahong,  Geng Chao,  Liu Shengnan,  Wang Qi,  Li Xiaorong,  Zhang Yan DOI: 10.3760/cma.j.cn115985-20190616-00262 Published 2020-04-10 Cite as Chin J Exp Ophthalmol, 2020,38(04): 291-299. Abstract Objective To study the methylation level of retinal gene promoter region in a rat model of type 1 diabetes (T1D) and investigate the correlation between DNA methylation level and retinal […]