Clinical features of cancer-associated retinopathy

Authors: Li Hui,  Yang Lizhu,  Zou Xuan,  Sun Zixi,  Sui Ruifang

DOI: 10.3760/cma.j.issn.2095-0160.2018.10.011
Published 2018-10-10
Cite as Chin J Exp Ophthalmol, 2018,36(10): 786-790.

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To analyze the clinical features of cancer-associated retinopathy (CAR).


The clinical data of 10 patients who diagnosed as CAR during 5 years were retrospectively analyzed.All patients underwent detailed ocular examinations, including electroretinogram (ERG), optical coherence tomography (OCT), visual field (VF) and autofluorescence(AF).


The primary malignancy was lung carcinoma in 3 patients, thymoma in 3 patients, thyroid carcinoma in 1 patients, maxillary sinus tumor in 1 patients, nasopharyngeal carcinoma in 1 patients and rectal cancer in 1 patients.All patients complained progressive visual reducing.Three patients manifested night blindness.The best corrected visual acuity (BCVA)<0.1 was in three eyes, ≤0.1-<0.5 in seven eyes, and ≥0.5 in ten eyes.Patients showed normal fundi or mild abnormality.OCT images showed disorganization and/or loss of the ellipsoid zone in the macular area in 4 patients, and other six patients had only central foveal ellipsoid zone preserved.Eight patients had moderately or severely reduced ffERG, and 2 patients demonstrated electro-negative ERG.Five patients revealed peripheral visual defect.AF images were from normal to low or high AF patches in the posterior pole and mid-peripheral retina.


The clinical manifestations of CAR are varied as common characteristics of progressive visual decrease with or without night blindness, visual field defect and abnormal ffERG recording.

Key words:

Cancer-associated retinopathy; Immune retinopathy; Clinical features

Contributor Information

Li Hui
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
Yang Lizhu
Zou Xuan
Sun Zixi
Sui Ruifang
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Updated: February 10, 2023 — 3:00 am