Comparison between endoscopic surgery and glucocorticoid therapy for traumatic optic neuropathy: a meta-analysis

Authors: Yu Jinhai,  Wu Yan,  Wang Yaohua,  Xu Qihua,  Xiong Chao,  Liao Hongfei
DOI: 10.3760/cma.j.cn115989-20201130-00809
Published 2023-01-10
Cite as Chin J Exp Ophthalmol, 2023, 41(1): 42-46.

Abstract                                    [Download PDF] [Read Full Text]

Objective

To systematically analyze the efficacy of nasal endoscopic transsphenoidal decompression and glucocorticoid pulse therapy for traumatic optic neuropathy (TON).

Methods

PubMed, Web of Science, Cochrane Library, ClinicalTrial.gov, CNKI, Wanfang, China Biomedical and other databases were searched to retrieve clinical studies on endoscopic surgery and hormone therapy for TON since their establishment to November 1, 2020.Two researchers screened the literature and evaluated the quality of the included literatures.The improvement of visual acuity before and after treatment was taken as an effective indicator.RevMan 5.3 statistical software was used for meta-analysis.The sensitivity of the results was analyzed atfer literature exclusion.The publication bias of each study was double checked by funnel plot and Begg test.

Results

Eight studies were included, including 7 cohort studies and 1 randomized controlled trial.There was no significant difference between the endoscopic decompression group and glucocorticoid group in the efficiency of visual acuity improvement in the treatment of TON [odds ratio (OR)=1.65, 95% confidence interval (CI)∶0.75-3.66, P=0.22], neither in TON patients with residual vision before surgery (OR=2.17, 95%CI: 0.94-4.98, P=0.07). For nasal endoscopic decompression surgery, early surgery (disease course<7 days) was more effective than late surgery (disease course>7 days) (OR=4.73, 95%CI: 2.55-8.78, P<0.01). Sensitivity analysis suggested that the results of this literature analysis were not robust.The Begg test showed that there was no literature publication bias.

Conclusions

There is no significant difference between nasal endoscopic surgery and glucocorticoid therapy in the treatment of TON.Early endoscopic surgery may help improve visual acuity in patients with residual vision.

Key words:

Endoscopy; Optic neuropathy, traumatic; Hormone therapy; Treatment outcome

Contributor Information

Yu Jinhai

Department of Orbital Disease Section, Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Nanchang 330006, China

Wu Yan

Graduate School of Nanchang University, Nanchang 330031, China

Wu Yan is now working at Department of Ophthalmology, The Second People’s Hospital of Jingdezhen, Jingdezhen 333000, China

Wang Yaohua

Department of Orbital Disease Section, Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Nanchang 330006, China

Xu Qihua

Department of Orbital Disease Section, Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Nanchang 330006, China

Xiong Chao

Department of Orbital Disease Section, Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Nanchang 330006, China

Liao Hongfei

Department of Orbital Disease Section, Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Nanchang 330006, China

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