Contrast-enhanced ultrasound characteristics of choroidal hemangioma

Authors: She Haicheng,  Li Dongjun,  Yang Wenli,  Chen Wei,  Wang Ziyang,  Wei Wenbin
DOI: 10.3760/cma.j.issn.2095-0160.2015.01.011
Published 2015-01-10
Cite as Chin J Exp Ophthalmol, 2015,33(1): 51-54.

Abstract                              [Download PDF] [Read Full Text]


Choroidal hemangioma is a common benign intraocular tumor.Typical choroidal hemangioma is comparably easy to diagnose, but untypical one might be misdiagnosed as malignant tumor.Contrast-enhanced ultrasound (CEUS) has been used to diagnose multiple neoplasm for the past few years.However, the application of CEUSin ophthalmology is less.


This study was to investigate the CEUS characteristics of choroidal hemangioma.


Fifty-eight eyes of 58 patients who were diagnosed as choroidal hemangioma were included in Beijing Tongren Hospital during July 2010 to December 2012.CEUS was performed on the patients to check the manifestations of choroidal hemangioma.A time-intensity analysis was employed to quantitatively analyzed and compared the maximum intensity (MI), rising time (RT), time to peak (TTP), and mean transit time (mTT) between the choroidal hemangioma and normal orbital tissue and the parameters were contrasted using Wilcoxon signed-rank test.


CEUS showed that choroidal hemangioma was gradually enhanced by the contrast after intravenous injection of sulphur hexafluoride microbubbles with a high-reference signal in choroidal hemangioma, and the fading procedure was slower in choroidal hemangioma than that of normal orbital tissue.MI, RT, TTP, and mTT were 294.20% (217.35%, 373.25%), 21.30 (17.35, 23.35) s, 25.00 (21.68, 27.48) s and 59.30 (51.08, 78.35) s in the choroidal hemangioma, which were significantly higher than 100.00% (100.00%, 100.00%), 17.75 (15.00, 20.30) s, 22.40 (18.35, 24.63) s and 47.25 (40.90, 57.23) s in the normal orbital tissue (Z=-6.608, -4.998, -4.650, -4.332, all at P<0.001).


Choroidal hemangioma has its own CEUS manifestation characteristics. CEUS is helpful to the differential diagnosis of choroidal hemangioma.

Key words:

Choroid; Choroidal neoplasm/diagnosis; Hemangioma/diagnosis; Contrast-enhanced ultrasound

Contributor Information

She Haicheng
Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Li Dongjun
Yang Wenli
Chen Wei
Wang Ziyang
Wei Wenbin
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