Diagnosis value of shortwave autofluorescence for cystoid macular edema

Authors: Shen Zhaomeng,  Zhang Linyi,  Zhang Xian,  Wei Wei,  Li Zhiguo
DOI: 10.3760/cma.j.issn.2095-0160.2015.01.012
Published 2015-01-10
Cite as Chin J Exp Ophthalmol, 2015,33(1): 55-59.

Abstract                             [Download PDF] [Read Full Text]


Cystoid macular edema (CME) is a manifestation secondary to multiple fundus diseases and often leads to the decline of visual acuity.Optical coherence tomography (OCT) is a common diagnostic method for CME, but it can not reflect the metabolism information of retinal pigment epithelium (RPE).Shortwave autofluorescence (SW-AF)may find the abnormality of macula, but its clinical value remains to be confirmed.


This study was to investigate the value of SW-AF in the diagnosis of CME.


One hundred and eighty-nine eyes of 140 patients who have the relative diseases to CME or received intraocular surgery were included from May 2010 to August 2011 in Lihuili Hospital of Ningbo city.SW-AF, infrared autofluorescence (IR-AF), fundus fluorescein angiography (FFA) and OCT were performed in all the eyes under the informed consent of each patient.The sensitivity, specificity and other indicators in diagnostic test of SW-AF for CME were evaluated and compared with OCT.


SW-AF had certain accuracy in diagnosis of CME with the sensitivity 78.29%, specificity 96.67%, Youden index 0.75, positive predictive value 98.06%, negative predictive value 67.44%.The area under curve (AUC) of SW-AF for the diagnosis of CME was 0.875 with the 95% confidence interval (CI) 0.823-0.926 (P<0.001).Compared with OCT, the differences of SW-AF and IR-AF in the diagnosis for CME was statistically significant(χ2=22.53, 91.35, both at P<0.001), and agreement coefficients of diagnosis result between SW-AF、IR-AF or FFA and OCT were 0.67, 0.12 and 0.85.


SW-AF can be used as a new rapid, non-invasive, ancillary technique in diagnosis of CME with certain accuracy, and the diagnostic agreement of SW-AF with OCT is lower than FFA but is higher than IR-AF.

Key words:

Macular edema/diagnosis; Fundus autofluorescence; Tomography, optical coherence; Fundus fluorescein angiography; Lipofuscin/metabolism; Diagnostic test

Contributor Information

Shen Zhaomeng
Department of Ophthalmology, Lihuili Hosptial of Ningbo, Ningbo 315040, China
Zhang Linyi
Zhang Xian
Wei Wei
Li Zhiguo
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