Correlation between retinal glial cells and proliferative vitreoretinopathy

Authors: Li Xue,  Li Xiaohua
DOI: 10.3760/cma.j.cn115989-20191113-00494
Published 2022-12-10
Cite as Chin J Exp Ophthalmol, 2022, 40(12): 1197-1201.

Abstract                              [View PDF] [Read Full Text]

Proliferative vitreoretinopathy (PVR) is a common complication of retinal detachment surgery, also an important blinding cause.Besides retinal pigment epithelial cells, retinal glial cells also are mainly involved in the formation and development of PVR.Retinal glial cells include Müller cells, astrocytes and microglia.The glial cells not only can be activated to change the morphology of cells, but also secrete growth factors and cytokines, synthesize extracellular matrix, and participate in the formation of PVR.The factors and synthetic extracellular matrix secreted by retinal glial cells promote the proliferation of retinal glial cells, which accelerates the development of PVR.This article described the interaction between the activation of retinal glial cells, astrocytes, growth factors secreted, cytokines secreted, extracellular matrix synthesized by glial cells and PVR formation, and the effect of non-coding RNAs on glial cells and PVR.

Key words:

Retinal glial cells; Proliferative vitreoretinopathy; Epithelial-mesenchymal transition

Contributor Information

Li Xue

Department of Ophthalmology, Henan Provincial People’s Hospital, Henan Eye Hospital, Henan Eye Institute, Henan Key Laboratory of Ophthalmology and Visual Science, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University, Zhengzhou 450003, China

Li Xiaohua

Department of Ophthalmology, Henan Provincial People’s Hospital, Henan Eye Hospital, Henan Eye Institute, Henan Key Laboratory of Ophthalmology and Visual Science, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University, Zhengzhou 450003, China

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