Diagnostic value of OCTA and FFA in central serous chorioretinopathy complicated with choroidal neovascularization: a meta-analysis

Objective

To systematically evaluate the diagnostic value of optical coherence tomography angiography (OCTA) and fluorescein fundus angiography (FFA) for choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC).

Methods

PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Internet (CNKI), VIP database and Wanfang Database were searched for literature published from January 1991 to March 2020 with CSC patients as subjects and OCTA and FFA as diagnostic methods of CNV.The quality of the included literature was evaluated with Australian JBI tool.A meta-analysis was performed using Review Manager 5.3 software.The source of heterogeneity was identified by age and total number of samples subgroup analysis.

Results

Nine studies with a total sample size of 374 eyes were enrolled.The quality score of 8 studies was greater than 14.The detection rate of CNV in CSC by OCTA was higher than that by FFA [odds ratio(OR)=3.99, 95% confidence interval(CI): 1.44-11.07, P<0.001].Studies with sample size >40 showed no heterogeneity (I²=49%, P=0.14), suggesting that sample size might be a source of heterogeneity.Publication bias was found by funnel plot.

Conclusions

OCTA has a higher detection rate of CNV secondary to CSC than FFA, and it can be used as a routine inspection method.

Choroidal neovascularization; Central serous chorioretinopathy; Optical coherence tomography angiography; Fluorescein fundus angiography; Meta-analysis