Effects of ubiqutin-proteasome system in retinopathy and their mechanism

Authors: Wang Shuai,  Liu Shengqiang

DOI: 10.3760/cma.j.issn.2095-0160.2019.10.015
Published 2019-10-10
Cite as Chin J Exp Ophthalmol, 2019,37(10): 843-848.

Abstract

Ubiquitin-proteasome system (UPS) is the important protein degradation system in eukaryotic cells, participates in cell cycle, gene transcription, antigen-presenting, cell proliferation and differentiation, signal transduction and many other physiological processes.UPS dysfunction relates to pathogenic mechanisms in a variety of diseases such as cancer, neurodegenerative diseases and cardiovascular disease.In recent years, more and more researches confirmed that UPS exists in the retina, some retinal damage appeared in patients with neurodegenerative conditions.UPS is involved in the pathogenesis of diabetic retinopathy, age-related macular degeneration, macular pigment degeneration and other retinal diseases by regulating retinal oxidative stress, inflammation, angiogenesis, nerve damage, signal transduction and so on.Some signaling pathways, such as nuclear factor κB (NF-κB), transforming growth factor-β (TGF-β) and reactive oxygen species (ROS) play an important role.Their proteins degradation and synthesis of imbalances have a significant impact on the pathophysiological process of retinal diseases.Proteasome inhibitors can reduce inflammation pathological changes in retinal lesions.This review focused on the research progress of UPS in the development of retinopathy.

Key words:

Ubiquitin-proteasome system; Diabetic retinopathy; Age-related macular degeneration; Macular pigment degeneration; Physiopathologic mechanism

Contributor Information

Wang Shuai
Department of Ophthalmology, The Second Hospital of Dalian Medical University, Dalian 116027, China
Liu Shengqiang
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Updated: October 28, 2019 — 1:46 am