Epigenetics—the new era of biomedical and ophthalmological research

Authors:He Shikun,  Ouyang Sha
DOI: 10.3760/cma.j.issn.2095-0160.2016.10.001
Published 2016-10-10
Cite as Chin J Exp Ophthalmol, 2016,34(10): 865-873.

Abstract

Epigenetics is a researching hot topic of worldwide now.Increasing evidence shows that the pathogenesis of human diseases is not only influenced by the abnormalities of genetic factors but also by epigenetic mechanisms.Recent technological advances in epigenomic profiling has led to further understanding of the role epigenetic factors played in development, inflammation, aging, immunity, angiogenesis, tumorigenesis, and stem cell biology.The researchers in ophthalmology should pay close attention to the current research of major epigenetic mechanisms and their involvement in human diseases, especially ocular diseases.Moreover, the potential application of epigenetic drugs in the treatment of common human diseases also should be understood.Finally, the challenges and future perspectives underlying epigenetic research are discussed in this editorial paper.

Key words:

Epigenetics; Ocular disease; DNA methylation; Histone modification; Non-coding RNA

Contributor Information

He Shikun
南加州大学Keck医学院眼科及病理系, USC Roski眼科研究所, 洛杉矶, CA90033, 美国
Ouyang Sha
南加州大学Keck医学院眼科及病理系, USC Roski眼科研究所, 洛杉矶, CA90033, 美国;410000 长沙, 中南大学湘雅医院眼科
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