Influencing factors and research progress in the mouse model of myopia

In recent years, the high prevalence of myopia has become a global public health concern.Understanding the mechanism will help to achieve precise prevention and treatment of myopia.Animal models are important tools for studying the pathogenesis and prevention strategies.Mice are commonly used in myopia research, because they are easy to breed, feed and genetically manipulate.However, their small eye size makes it difficult to accurately measure the changes in biological parameters such as refraction and axial length.In addition, the refractive developmental pattern of mice is opposite to that of humans.This article reviews the structural features of the mouse cornea, lens, vitreous body, retina and sclera, the pattern of refractive development, and the latest progress about the establishment and evaluation of murine myopia models to provide some hints and references for further research.

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