Influencing factors of recurrence of macular edema secondary to retinal vein occlusion

Retinal vein occlusion (RVO) is a common retinal vascular disease, and macular edema (ME) is the most common cause of visual impairment in eyes with RVO.Intravitreal injection of anti-vascular endothelial growth factor (VEGF) has been advocated as a first-line therapy for ME secondary to RVO.After anti-VEGF treatment, the patient’s visual function recovers well in the short term, but the long-term efficacy is unstable and the recurrence rate of ME is high.Therefore, it is of great clinical value to predict the factors influencing the recurrence of ME, which would help determine which patients should receive frequent follow-up and more aggressive treatment to achieve better clinical outcomes.In this paper, the influencing factors of recurrence of ME secondary to RVO are summarized, including disorganization of retinal inner layer, change in the macular microvascular structure, change in choroid thickness, the non-perfusion area between different areas of the retina, inflammatory cytokines, retinal blood flow and blood flow velocity, etc., which can provide an important basis for patient counseling, clinical diagnosis and treatment and prognostic follow-up.

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