DOI: 10.3760/cma.j.cn115989-20211130-00661
Published: 2025 -01 -10
Citation
Li Zhaojin, Di Yu. Research progress on the regulatory effect of lncRNA MALAT1 on neovascularization in ischemic retinopathy[J]. Chin J Exp Ophthalmol, 2025, 43(01):92-96. DOI: 10.3760/cma.j.cn115989-20211130-00661.
ABSTRACT [Download PDF] [Read Full Text]
Ischemic retinopathies (IRs) with neovascularization often severely impair vision and even lead to blindness.Studies have shown that long non-coding RNA (lncRNA) MALAT1 is co-expressed with protein-coding genes that regulate retinal cell development.Recent studies have also confirmed that MALAT1 is up-regulated in IRs and has the effects of inducing oxidative stress and inflammatory responses, promoting vascular endothelial cell proliferation, migration and angiogenesis, and changing epigenetic modifications, which plays an important role in the pathogenesis and regulation of retinal neovascularization.This article summarizes the current research status of MALAT1 in IRs from the aspects of the pathogenesis of IRs, the expression and function of MALAT1 in the retina and its role in angiogenesis, oxidative stress, inflammation, vascular endothelial damage, epigenetic regulation, cell cycle, etc., and explores its role in the occurrence and development of retinal neovascularization to provide a deeper understanding of the mechanism of MALAT1 in the neovascularization of IRs to help develop its targeted treatment strategies.