Long-term clinical outcomes of gonioscopy-assisted transluminal trabeculotomy in primary open-angle glaucoma

Published: 2026 -06 -10

DOI: 10.3760/cma.j.cn115989-20250730-00249

Citation

Jin Xin, Li Wanxia, Yang Xiaoyuan, et al. Long-term clinical outcomes of gonioscopy-assisted transluminal trabeculotomy in primary open-angle glaucoma[J]. Chin J Exp Ophthalmol, 2026, 44(6):548-553. DOI: 10.3760/cma.j.cn115989-20250730-00249.

ABSTRACT [Download PDF] [Read Full Text]

Objective To evaluate the efficacy and safety of gonioscopy-assisted transluminal trabeculotomy (GATT) in the treatment of primary open-angle glaucoma (POAG).

Methods A retrospective cohort study was conducted. Seventy patients (83 eyes) with POAG treated at Henan Eye Hospital from January 2018 to May 2022 were included. Among them, 38 patients (50 eyes) underwent GATT and 32 patients (33 eyes) underwent trabeculectomy (TRAB) according to their willingness. Visual acuity, intraocular pressure measurement with a non-contact tonometer, slit-lamp microscopy, use of intraocular pressure-lowering drugs, and postoperative complications were recorded before and at 1, 6, 12, 18 and 24 months after the operation. This study followed the Declaration of Helsinki. The study protocol was reviewed and approved by the Ethics Committee of Henan Eye Hospital (No. HNEEC-2023[32]). All patients voluntarily signed the informed consent form before surgery.

Results There was a significant overall comparison difference in IOP among different time points ( F _time=52.336, P<0.001), and there was no statistical significance in IOP between the two groups ( F _group=2.443, P=0.119). The amount of intraocular pressure-lowering drugs at the last follow-up after surgery in both GATT and TRAB groups was lower than that before surgery, and the differences were statistically significant (Z=-5.754, -3.847; both P<0.001). There was no significant difference in the number of drugs used at the last follow-up visit between the GATT group and the TRAB group ( Z=-0.777, P=0.437). There was no significant difference in preoperative and final postoperative follow-up visual acuity between the GATT group and the TRAB group (Z=-0.578, -0.638; both P>0.05). The cumulative conditional success rates in the GATT group and the TRAB group were 96.2% and 89.7%, respectively, and the cumulative complete success rates were 66.7% and 43.8%, respectively, with no significant difference between them ( χ ²=1.633, P=0.201; χ ²=3.534, P=0.060). No serious complications were observed in either group after operation.

Conclusions GATT is safe and effective in the long-term follow-up for POAG, with a complete success rate comparable to TRAB.