Mechanism of curcumin in the treatment of diabetic retinopathy based on network pharmacology and molecular docking

Authors: Du Yuanyuan,  Wang Yiyun,  Zhao Rong,  Zhang Ji,  Ji Xiaoyan,  Lu Jiayu,  Ji Fangfang,  Lou Hui,  Jiang Ziyuan,  Huang Jiang
DOI: 10.3760/cma.j.cn115989-20220314-00105
Published 2023-12-10
Cite as Chin J Exp Ophthalmol, 2023, 41(12): 1152-1159.

Abstract                              [Download PDF] [Read Full Text]

Objective

To investigate the mechanism of curcumin in the treatment of diabetic retinopathy (DR) by network pharmacology and molecular docking.

Methods

The compounds targets of curcumin were predicted by SEA and SwissTargetPrediction databases, and the DR target genes were obtained by CTD database.The different genes were mapped and matched by Venny database to screen their intersections.The intersecting genes were submitted to GeneMANIA database to construct a protein-protein interaction network.WebGestalt database was used to conduct enrichment analysis and AutoDock Vina was used to perform molecular docking of the core targets.

Results

A total of 52 targets of curcumin, 1 599 targets of DR and 48 intersecting targets were detected.The core targets were serine/threonine-protein kinase 1 (AKT1), tumor necrosis factor-α (TNF-α), epidermal growth factor receptor (EGFR), signal transduction and activator of transcription 3 (STAT3) and heat shock protein 90 alpha family class A member 1 (HSP90AA1). Enrichment analysis suggested that these targets were mainly associated with signaling pathways, including the EGFR tyrosine kinase inhibitor resistance signaling pathway, hypoxia-inducible factor-1 (HIF-1) signaling pathway, interleukin (IL)-17 signaling pathway and advanced glycosylation end product-the receptor of advanced glycosylation end product (AGE-RAGE) signaling pathway.

Conclusions

Curcumin may play an important role in the treatment of DR by regulating multiple signaling pathways to inhibit the inflammatory response and combat oxidative stress.

Key words:

Curcumin; Diabetic retinopathy; Network pharmacology; Genes

Contributor Information

Du Yuanyuan

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

Wang Yiyun

Suzhou Medical College of Soochow University, Suzhou 215123, China

Zhao Rong

Suzhou Medical College of Soochow University, Suzhou 215123, China

Zhang Ji

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

Ji Xiaoyan

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

Lu Jiayu

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

Ji Fangfang

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

Lou Hui

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

Jiang Ziyuan

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

Huang Jiang

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China

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