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Retinal detachment(RD)is one of the most common sight-threatening retinal diseases.Visual acuity is not always restored after successful reattachment of the retina.Photoreceptor cell death has been thought to be the major cause of vision loss after RD through various pathways and their interactions, including caspase-dependent apoptosis, endoplasmic reticulum stress-induced apoptosis and non-apoptotic death forms, such as necroptosis, autophagy, and so on.Based on the understanding of the mechanism of photoreceptor cell death after RD, current efforts on combinatorial inhibition of multiple death pathways, targeting upstream molecules and enhancement of intrinsic neuroprotection would help us to protect photoreceptors effectively and improve visual acuity of RD patients.This review summarized current opinions on mechanisms of photoreceptor cell death and the potential treatment strategies.