Mechanisms of photoreceptor cell death and potential treatment strategies in retinal detachment

Authors:Li Tong,  Sun Xiaodong
DOI: 10.3760/cma.j.issn.2095-0160.2016.12.020
Published 2016-12-10
Cite as Chin J Exp Ophthalmol, 2016,34(12): 1140-1144.

Abstract

Retinal detachment(RD)is one of the most common sight-threatening retinal diseases.Visual acuity is not always restored after successful reattachment of the retina.Photoreceptor cell death has been thought to be the major cause of vision loss after RD through various pathways and their interactions, including caspase-dependent apoptosis, endoplasmic reticulum stress-induced apoptosis and non-apoptotic death forms, such as necroptosis, autophagy, and so on.Based on the understanding of the mechanism of photoreceptor cell death after RD, current efforts on combinatorial inhibition of multiple death pathways, targeting upstream molecules and enhancement of intrinsic neuroprotection would help us to protect photoreceptors effectively and improve visual acuity of RD patients.This review summarized current opinions on mechanisms of photoreceptor cell death and the potential treatment strategies.

Key words:

Retinal detachment; Photoreceptor; Apoptosis; Necroptosis; Autophagy

Contributor Information

Li Tong
Department of Ophthalmology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai 200080, China
Sun Xiaodong
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