Research advances in relationship between substance P and neurotrophic keratopathy and its application

Authors: Wan Shanshan,  Zhou Qingjun,  Xie Lixin

DOI: 10.3760/cma.j.issn.2095-0160.2019.03.015
Published 2019-03-10
Cite as Chin J Exp Ophthalmol, 2019,37(3): 233-237.

Abstract

Neurotrophic keratopathy is caused by a variety of factors that damage the corneal sensory nerves, resulting in hypoesthesia of cornea, corneal dystrophy and inflammatory changes.The manifestations of neurotrophic keratopathy are recurrent or persistent corneal epithelial defects, delayed corneal wound healing, corneal ulcers and even perforation.There are still some difficulties in therapy targeting to nerve plerosis.Substance P, as a neurotransmitter, is expressed in ophthalmic nerves and many cell types, including corneal epithelial cells, stromal cells and immunological cells, and exerts its biological functions by activating intracellular signaling pathways.Recently, with the increasing researches of substance P, the treatment of neurotrophic keratopathy is gradually changing.This paper retrospected the clinical features and pathogenesis of neurotrophic keratopathy, summarized the association between substance P and neurotrophic keratopathy from the perspective of infection, surgery and systemic disease, and the prospects of substance P application in neurotrophic keratopathy.

Key words:

Neurotrophic keratopathy; Substance P; Herpesvirus infection; Ophthalmic operations; Diabetes

Contributor Information

Wan Shanshan
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Zhou Qingjun
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, China
Xie Lixin
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, China
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Updated: September 3, 2019 — 1:40 pm