The relation between chemokines and retinal vein occlusion

Authors: Liu Mingyue,  Liu Hongling

DOI: 10.3760/cma.j.issn.2095-0160.2019.03.016
Published 2019-03-10
Cite as Chin J Exp Ophthalmol, 2019,37(3): 238-240.

Abstract

Chemokines are a family of cytokines that induce leukocyte recruitment in inflammation and immune responses.Studies have confirmed that chemokines are associated with retinal vein occlusion (RVO), such as high expression of interleukin-8 (IL-8), monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1) in the eyes of RVO.Some chemokines, such as MCP-1 and IL-8 can aggravate macular edema and retinal ischemia in patients with RVO.For the treatment of RVO, the application of triamcinolone acetonide (TA) and anti-vascular endothelial growth factor (anti-VEGF) drugs has also been proved to inhibit the expression of some chemokines in the eyes, and the therapeutic effect is correlated with the level of initial chemokines.This article will introduce the research progress on the correlation between chemokines and RVO from the above aspects.

Key words:

Chemokines; Retinal vein occlusion; Interleukin-8; Monocyte chemotactic protein-1; Triamcinolone acetonide; Anti-vascular endothelial growth factor

Contributor Information

Liu Mingyue
Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Liu Hongling
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Updated: September 3, 2019 — 1:40 pm