Research of immunoregulation effects of regulatory T cells in dry eye disease

Authors: Wang Huifeng,  Ruan Qingguo,  Xie Lixin
DOI: 10.3760/cma.j.cn115989-20190618-00268
Published 2022-08-10
Cite asChin J Exp Ophthalmol, 2022, 40(8): 771-774.

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Dry eye disease is a multifactorial disease affecting the ocular surface, lacrimal glands and meibomian glands.Its incidence is gradually increasing and tends to occur in the younger.Its main features are ocular surface inflammation caused by tear film instability and high osmotic pressure of tears.Moreover, there is a vicious circle between inflammation and ocular surface damage.Immune-related inflammatory responses play a key role in this process.Regulatory T cell (Treg) is a subset of T cells with immunoregulatory functions, which are closely related to the occurrence and development of dry eye, and can inhibit the inflammation of dry eyes by acting on antigen-presenting cells and T helper cell (Th)1/Th17.Recent studies have shown that Treg in dry eye is abnormal in number or function and closely related to the risk factors of dry eye such as age and gender.In addition, by increasing the number of Tregs and promoting their differentiation to alleviate inflammatory response can provide new treatment strategies in dry eye.The correlation between Treg and dry eye and its related research in the pathogenesis and treatment of dry eye were reviewed in this article.

Key words:

Regulatory T cell; Regulatory/immunology; Dry eye; Inflammation/immunology; Immunoregulation

Contributor Information

Wang Huifeng

Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao 266071, China

Ruan Qingguo

Eye institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China

Xie Lixin

Eye institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China

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